Researcher
Hilde Brems
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Neurofibromatosis Research (Division)
Responsible
From15 Jul 2022 → Today - Laboratory for Neurofibromatosis Research (Division)
Member
From19 Oct 2009 → 30 Sep 2017 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 7 of 7
- Molecular and functional characterization of Legius syndrome and related disorders: Improved diagnosis and understanding of the underlying mechanisms.From1 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of new analytic tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases”From1 Aug 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Importance of SPRED1 in melanomaFrom9 Dec 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Importance of SPRED1 in melanomaFrom1 Oct 2015 → 27 Mar 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Periosteal cell therapy as a new treatment of pseudarthrosis in children with NF1.From21 Oct 2013 → 10 Dec 2019Funding: IWT personal funding - strategic basic research grants, BOF - Doctoral projects
- Pathogenesis of congenital tibial bowing and pseudarthrosis in neurofibromatosis type 1.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project
- NF1-like syndromes: identification of new genes and further characterization of Legius syndrome using the mouse model.From1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
Publications
41 - 50 of 84
- NF1-Related Pseudarthrosis: Beyond the Pseudarthrosis Site.(2017)
Authors: Carlijn Brekelmans, Silke Hollants, Caroline De Groote, Marijke Spaepen, Natalie Sohier, Marina Marechal, Frank Luyten, Johan Lammens, Eric Legius, Hilde Brems
Pages: S394 - S394 - Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K-AKT-mTOR Pathways(2017)
Authors: Sarah Borrie, Hilde Brems, Eric Legius, Claudia Bagni
Pages: 115 - 142 - Erratum to: Prevalence of neurofibromatosis type 1 in congenital pseudarthrosis of the tibia(2017)
Authors: Kjell Van Royen, Hilde Brems, Eric Legius, Johan Lammens, Armand Laumen
Pages: 993 - 993 - Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study (vol 6, 20010, 2016)(2017)
Authors: A Carlier, Hilde Brems, JMA Ashbourn, I Nica, Eric Legius, L Geris
- Choroidal abnormalities in café-au-lait syndromes: A new differential diagnostic tool ?(2017)
Authors: Catherine Cassiman, Ingele Casteels, Julie Jacob, Ellen Plasschaert, Hilde Brems, Karel Van Keer, Eric Legius
Pages: 529 - 535 - Prevalence of neurofibromatosis type 1 in congenital pseudarthrosis of the tibia(2016)
Authors: Hilde Brems, Eric Legius, Johan Lammens
Pages: 1193 - 1198 - Recurrent multilocular mandibular giant cell granuloma in neurofibromatosis type 1: Evidence for second hit mutation of NF1 gene in the jaw lesion and treatment with curettage and bone substitute materials(2016)
Authors: Eric Legius, Hilde Brems
Pages: 1054 - 1060 - Interaction between a domain of a negative regulator of the RAS-ERK pathway, SPRED1, and the GTPase-Activating Protein-Related Domain of neurofibromin is implicated in Legius Syndrome and Neurofibromatosis Type 1(2016)
Authors: Hilde Brems, Ludwine Messiaen, Eric Legius
Pages: 3124 - 34 - SPRED1 and Legius syndrome(2016)
Authors: Hilde Brems, Ludwine Messiaen, Eric Legius, Robert P Erickson, Anthony J Wynshaw-Boris
Pages: 639 - 641 - Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study(2016)
Authors: Aurélie Carlier, Hilde Brems, Ioana Gabriela Nica, Eric Legius, Liesbet Geris
Pages: 20010