Researcher
Hilde Brems
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Neurofibromatosis Research (Division)
Responsible
From15 Jul 2022 → Today - Laboratory for Neurofibromatosis Research (Division)
Member
From19 Oct 2009 → 30 Sep 2017 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 7 of 7
- Molecular and functional characterization of Legius syndrome and related disorders: Improved diagnosis and understanding of the underlying mechanisms.From1 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of new analytic tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases”From1 Aug 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Importance of SPRED1 in melanomaFrom9 Dec 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Importance of SPRED1 in melanomaFrom1 Oct 2015 → 27 Mar 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Periosteal cell therapy as a new treatment of pseudarthrosis in children with NF1.From21 Oct 2013 → 10 Dec 2019Funding: IWT personal funding - strategic basic research grants, BOF - Doctoral projects
- Pathogenesis of congenital tibial bowing and pseudarthrosis in neurofibromatosis type 1.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project
- NF1-like syndromes: identification of new genes and further characterization of Legius syndrome using the mouse model.From1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
Publications
31 - 40 of 84
- Multidisciplinary Approach to Neurofibromatosis Type 1(2020)
Authors: Gianluca Tadini, Eric Legius, Hilde Brems
- NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation(2020)
Authors: Hilde Brems, Eric Legius
Pages: 157 - 174 - Neurofibromatosis type 1-related pseudarthrosis(2019)
Authors: Carlijn Brekelmans, Eric Legius, Hilde Brems, Johan Lammens
- Neurofibromatosis type 1-related pseudarthrosis: Beyond the pseudarthrosis site(2019)
Authors: Carlijn Brekelmans, Liesbet Geris, Frank Luyten, Raf Sciot, Thomy de Ravel de l'Argentière, Johan Lammens, Eric Legius, Hilde Brems
Pages: 1760 - 1767 - Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define pre-malignant neurofobromatosis type1-associated atypical neurofibromas(2019)
Authors: Hilde Brems, Eric Legius
Pages: 981 - 992 - Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening(2019)
Authors: Matteo Giovanni Maria Boretto, Nina Maenhoudt, Xinlong Luo, Aurélie Hennes, Bram Boeckx, Ruben Heremans, Indra Van Zundert, Hilde Brems, Benoit Cox, Marc Ferrante, et al.
Pages: 1041 - 1051 - Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination(2018)
Authors: Silvia Pandolfi, Maria Francesca Baietti, Paolo Carai, Paul Najm, Fabrizio Renzi, Layka Abbasi Asbagh, Michal Simicek, Hilde Brems, Eric Legius, Ludwine Messiaen, et al.
Pages: 1177 - 1182 - Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-related overgrowth spectrum: A brief report(2018)
Authors: Nele Zutterman, Veerle Labarque, Eric Legius, Hilde Brems
Pages: e186 - e188 - Nevus anemicus and RASopathies.(2018)
Authors: Petra De Haes, Ellen Denayer, Eric Legius, Hilde Brems
Pages: 390 - 391 - The Characteristics of 76 Atypical Neurofibromas as Precursors to Neurofibromatosis 1 Associated Malignant Peripheral nerve Sheath Tumors(2018)
Authors: Aljosja Rogiers, Steven Pans, Raf Sciot, Hilde Brems, Eric Legius
Pages: 818 - 825