Researcher
Hilde Brems
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Neurofibromatosis Research (Division)
Responsible
From15 Jul 2022 → Today - Laboratory for Neurofibromatosis Research (Division)
Member
From19 Oct 2009 → 30 Sep 2017 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 7 of 7
- Molecular and functional characterization of Legius syndrome and related disorders: Improved diagnosis and understanding of the underlying mechanisms.From1 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of new analytic tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases”From1 Aug 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Importance of SPRED1 in melanomaFrom9 Dec 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Importance of SPRED1 in melanomaFrom1 Oct 2015 → 27 Mar 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Periosteal cell therapy as a new treatment of pseudarthrosis in children with NF1.From21 Oct 2013 → 10 Dec 2019Funding: IWT personal funding - strategic basic research grants, BOF - Doctoral projects
- Pathogenesis of congenital tibial bowing and pseudarthrosis in neurofibromatosis type 1.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project
- NF1-like syndromes: identification of new genes and further characterization of Legius syndrome using the mouse model.From1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
Publications
51 - 60 of 84
- Diagnosis of Constitutional Mismatch Repair-deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents(2015)
Authors: Hilde Brems
Pages: 1017 - 1029 - Keratinocytic epidermal nevus syndrome with Schwann cell proliferation, lipomatous tumour and mosaic KRAS mutation(2015)
Authors: Said Farschtschi, Victor-Felix Mautner, Silke Hollants, Christian Hagel, Marijke Spaepen, Christoph Schulte, Eric Legius, Hilde Brems
Pages: 6 - Keratinocytic epidermal nevus syndrome with Schwann cell proliferation, lipomatous tumour and mosaic KRAS mutation(2015)
Authors: Silke Hollants, Eric Legius, Hilde Brems
Pages: 6 - PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies(2014)
Authors: Eline Beert, Hilde Brems, Eric Legius
Pages: 247 - 251 - Jaffe-Campanacci syndrome, revisited: detailed clinical and molecular analyses determine whether patients have neurofibromatosis type 1, coincidental manifestations, or a distinct disorder(2014)
Authors: Hilde Brems, Eric Legius, Ludwine Messiaen
Pages: 448 - 459 - SVA retrotransposon insertion-associated deletion represents a novel mutational mechanism underlying large genomic copy number changes with non-recurrent breakpoints(2014)
Authors: Eric Legius, Hilde Brems, Ludwine Messiaen
- Legius Syndrome, an Update.Molecular Pathology of Mutations in SPRED1(2013)
Authors: Hilde Brems, Eric Legius
Pages: 107 - 12 - Ubiquitin Ligase HUWE1 Regulates Axon Branching through the Wnt/beta-Catenin Pathway in a Drosophila Model for Intellectual Disability(2013)
Authors: Joke Vandewalle, Hilde Brems, Marijke Bauters, Elsa Lauwers, Peter Marynen, Patrik Verstreken, Bassem Hassan, Guy Froyen
- EPCAM germline and somatic rearrangements in lynch syndrome: identification of a novel 3 ' EPCAM deletion(2013)
Authors: Xavier Sagaert, Gert De Hertogh, Eline Beert, Gert Matthijs, Eric Legius, Hilde Brems
Pages: 845 - 854 - Multiple pilomatricomas with somatic CTNNB1 mutations in children with constitutive mismatch repair deficiency(2013)
Authors: Magdalena Chmara, Annekatrin Wernstedt, Bartosz Wasag, Hilde Peeters, Marleen Renard, Eline Beert, Hilde Brems, Tina Giner, Imke Bieber, Henning Hamm, et al.
Pages: 656 - 664