Researcher
Hilde Brems
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Neurofibromatosis Research (Division)
Responsible
From15 Jul 2022 → Today - Laboratory for Neurofibromatosis Research (Division)
Member
From19 Oct 2009 → 30 Sep 2017 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 7 of 7
- Molecular and functional characterization of Legius syndrome and related disorders: Improved diagnosis and understanding of the underlying mechanisms.From1 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of new analytic tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases”From1 Aug 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Importance of SPRED1 in melanomaFrom9 Dec 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Importance of SPRED1 in melanomaFrom1 Oct 2015 → 27 Mar 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Periosteal cell therapy as a new treatment of pseudarthrosis in children with NF1.From21 Oct 2013 → 10 Dec 2019Funding: IWT personal funding - strategic basic research grants, BOF - Doctoral projects
- Pathogenesis of congenital tibial bowing and pseudarthrosis in neurofibromatosis type 1.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project
- NF1-like syndromes: identification of new genes and further characterization of Legius syndrome using the mouse model.From1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
Publications
21 - 30 of 84
- MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders(2021)
Authors: Sarah Borrie, Rudi D'Hooge, Eric Legius, Hilde Brems
- A Patient with neonatal cholestasis.(2021)
Authors: Kristl Claeys, Eric Legius, Hilde Brems, David Cassiman, Pieter Vermeersch, Elena Levtchenko
Pages: 31 - 33 - Impaired instrumental learning in Spred1-/- mice, a model for a rare RASopathy.(2021)
Authors: Sarah Borrie, Eric Legius, Hilde Brems
- Comprehensive targeted next-generation sequencing approach in the molecular diagnosis of gastrointestinal stromal tumor(2021)
Authors: Isabelle Vanden Bempt, Sara Vander Borght, Raf Sciot, Lien Spans, Hilde Brems, Baki Topal, Patrick Schöffski, Eric Legius, Maria Debiec-Rychter
Pages: 239 - 249 - Genetic basis of neurofibromatosis type 1 and related conditions, including mosaicism(2020)
Authors: Eric Legius, Hilde Brems
Pages: 2285 - 2295 - Congenital enlargement of toes(2020)
Authors: Hilde Brems
Pages: 945 - 946 - Keratinocytic epidermal nevi associated with localized fibro-osseous lesions without hypophosphatemia(2020)
Authors: Ellen Denayer, Eric Legius, Elena Levtchenko, An Van Laethem, Hilde Brems
Pages: 890 - 895 - Examination of the genetic factors underlying the cognitive variability associated with neurofibromatosis type 1(2020)
Authors: Hilde Brems, Eric Legius
Pages: 889 - 897 - Analysis of 108 patients with endometrial carcinoma using the PROMISE classification and additional genetic analyses for MMR-D(2020)
Authors: Stefan Timmerman, Anne-Sophie Van Rompuy, Toon Van Gorp, Isabelle Vanden Bempt, Hilde Brems, Els Van Nieuwenhuysen, Sileny Han, Patrick Neven, Annouschka Laenen, Ignace Vergote
Pages: 245 - 251 - Mutational spectrum by phenotype: panel-based NGS testing of patients with clinical suspicion of RASopathy and children with multiple cafe-au-lait macules(2020)
Authors: Hilde Brems, Eric Legius
Pages: 264 - 275