Publicaties
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Late blocking of peripheral TNF-alpha is ineffective after spinal cord injury in mice Universiteit Hasselt
Spinal cord injury (SCI) is characterized by different phases of inflammatory responses. Increasing evidence indicates that the early chronic phase (two to three weeks after SCI) is characterized by a dramatic invasion of immune cells and a peak of pro-inflammatory cytokine levels, such as tumor necrosis factor-alpha (TNF-alpha) derived from the injured spinal cord as well as from injured skin, muscles and bones. However, there is substantial ...
Muscle endurance in elderly nursing home residents is related to fatigue perception, mobility, and circulating TNF-alpha, IL-6 and Hsp70. Vrije Universiteit Brussel
Objectives: To explore the relationships of muscle endurance with circulating Interleukin (IL)-6, Tumor Necrosis Factor (TNF)-alpha and Heat Shock Protein (Hsp)70 in nursing home residents, and to assess how muscle endurance related to self-perceived fatigue and mobility.
Design: Exploratory study
Setting: Three nursing homes of the Foundation for Psychogeriatrics (Brussels, Belgium).
Participants: Seventy-seven residents (53 ...
Design: Exploratory study
Setting: Three nursing homes of the Foundation for Psychogeriatrics (Brussels, Belgium).
Participants: Seventy-seven residents (53 ...
TNF-alpha and the IFN-gamma-inducible protein 10 (IP-10/CXCL-10) delivered by parvoviral vectors act in synergy to induce antitumor effects in mouse glioblastoma KU Leuven
Interferon-gamma-inducible protein 10 is a potent chemoattractant for natural killer cells and activated T lymphocytes. It also displays angiostatic properties and some antitumor activity. Tumor necrosis factor-alpha (TNF-alpha) is a powerful immunomodulating cytokine with demonstrated tumoricidal activity in various tumor models and the ability to induce strong immune responses. This prompted us to evaluate the antitumor effects of recombinant ...
An exploration of biosimilar TNF-alpha inhibitors uptake determinants in hospital environments in Italy, Portugal, and Spain KU Leuven
BACKGROUND: The availability of biosimilar medicines in Southern European markets has allowed purchasing biologics at a lower cost for healthcare systems. However, the capacity to seize this cost-reduction opportunity in the long run depends on fostering a sustainable competitive environment for all the market players involved. Diverse policies and information campaigns have been launched in Italy, Portugal and Spain to support uptake of ...
Biosimilar competition in European markets of TNF-alpha inhibitors: a comparative analysis of pricing, market share and utilization trends KU Leuven
Background: Factors like the number of biosimilar competitors and competitive pricing strategies from originator companies may influence price competition and biosimilar uptake. Objective: The aim of this study was to analyze multiple facets of biosimilar competition of TNF-alpha inhibitors in Europe by exploring the existence of a biosimilar first-mover advantage, pricing strategies of originator companies, and the evolution in patient access. ...
TL1A induces TCR independent IL-6 and TNF-alpha production and growth of PLZF(+) leukocytes Universiteit Gent
An elevated level of the cytokine TL1A is known to be associated with several autoimmune diseases, e. g. rheumatoid arthritis and inflammatory bowel disease. However, the mode of action of TL1A remains elusive. In this study, we investigated the role of TL1A in a pro-inflammatory setting, using human leukocytes purified from healthy donors. We show that TL1A, together with IL-12, IL-15 and IL-18, directly induces the production of IL-6 and ...
Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging KU Leuven
Immunity declines during aging, however the mechanisms involved in this decline are not known. In this study, we show that cutaneous delayed type hypersensitivity (DTH) responses to recall antigens are significantly decreased in older individuals. However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated antigen, or CD11a expression by CD4(+) T cells or their physical capacity for migration. Instead, there is ...
Cell line-dependent increase in cellular quercetin accumulation upon stress induced by valinomycin and lipopolysaccharide, but not by TNF-alpha Universiteit Gent
Influence of IL-6, IL-33, and TNF-alpha on human mast cell activation Universiteit Antwerpen
Background Mechanisms that govern priming and degranulation of human mast cells (MCs) remain elusive. Besides, most of our knowledge is based on experiments from which data only reflect an average of all stimulated cells. This study aims at investigating the effects of proinflammatory cytokines IL-6, IL-33, and TNF-α on IgE-dependent and IgE-independent activation of individual MCs. Methods MCs were derived from CD34+ progenitors isolated from ...