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Array comparative genomic hybridization analysis does not show genetic alterations in spermatozoa and offspring generated after spermatogonial stem cell transplantation in the mouse Vrije Universiteit Brussel
Abstract
BACKGROUND The most promising procedure to restore fertility in male childhood cancer patients is spermatogonial stem cell transplantation (SSCT). Although the efficiency of SSCT has been proven in the mouse model, its safety needs to be investigated too before considering any implementation in the clinic. To examine the incidence of genetic abnormalities after SSCT, the karyotypes of donor-derived spermatozoa and offspring were ...
BACKGROUND The most promising procedure to restore fertility in male childhood cancer patients is spermatogonial stem cell transplantation (SSCT). Although the efficiency of SSCT has been proven in the mouse model, its safety needs to be investigated too before considering any implementation in the clinic. To examine the incidence of genetic abnormalities after SSCT, the karyotypes of donor-derived spermatozoa and offspring were ...
Genetic Diagnosis in Mental Retardation: The Contribution of Array Comparative Genomic Hybridization KU Leuven
De implementatie van array comparatieve genomische hybridisatie (CGH) in het onderzoek van personen met een verstandelijke handicap en/ of dysmorfe kenmerken heeft geleid tot de identificatie van talrijke copy number variants (CNVs). De uitdaging bestaat erin om voor elke CNV de relatie tot het fenotype te bepalen. De afgelopen 50 jaar heeft de conventionele karyotypering inzichten gegeven omtrent grote genomische afwijkingen en deze ervaring ...
Evidence for genetic exchange and hybridization in Trypanosoma cruzi based on nucleotide sequences and molecular karyotype Instituut voor Tropische Geneeskunde
Genetic variation and hybridization in evolutionary radiations of cichlid fishes Universiteit Antwerpen
Evolutionary radiations are responsible for much of the variation in biodiversity across taxa. Cichlid fishes are well known for spectacular evolutionary radiations, as they have repeatedly evolved into large and phenotypically diverse arrays of species. Cichlid genomes carry signatures of past events and, at the same time, are the substrate for ongoing evolution. We survey genome-wide data and the available literature covering 438 cichlid ...
Interspecific hybridization in Sarcococca supported by analysis of ploidy level, genome size and genetic relationships KU Leuven Universiteit Gent Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Preimplantation genetic diagnosis using fluorescent in situ hybridization for cancer predisposition syndromes caused by microdeletions KU Leuven
BACKGROUND: Neurofibromatosis type 1 (NF1) and Von Hippel-Lindau (VHL) are dominantly inherited late onset cancer predisposition syndromes caused by mutations in the respective tumor suppressor genes (TSGs) NF1 and VHL. Less frequently TSGs are partially or fully deleted. Preimplantation genetic diagnosis (PGD) for cancer predisposition can be applied to select against the mutant allele in carrier couples. However, microdeletions within a single ...
Improving our Insight in the Genetic Origin of Congenital Heart defects using Array Comparative Genome Hybridization. KU Leuven
Chromosome investigations are still an important part of the genetic inv estigations in children with congenital heart defects (CHDs). For this, chromosomes from dividing white blood cells are investigated under a mic roscope to check if certain chromosomes or parts of chromosomes are pres ent in too many or too little copies. In the present work we have invest igated whether submicroscopic chromosome imbalances are a frequent cause for CHDs. We ...
Design of a comprehensive fluorescence in situ hybridization assay for genetic classification of T-cell acute lymphoblastic leukemia Universiteit Gent
The Use of Comparative Genomic Hybridization and Fluorescent In Situ Hybridization in Postmortem Pathology Investigation of Congenital Malformations KU Leuven
Chromosomal abnormalities are an important cause of multiple congenital anomalies (MCA). However, conventional cytogenetic analysis using culture is unsuccessful in 10% to 40% of the cases. The purpose of this study was to examine if retrospective chromosomal analysis was possible on paraffin-embedded autopsy material with new techniques, including comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). We ...