Karakterisatie van moleculaire mechanismen die hematopoietische reconstitutie van hematopoietische stamcellen verhogen. KU Leuven
The overarching goal of this proposal is to increase the number of "engrafting hematopoietic stem cells (HSC)" from umbilical cord blood (UCB), whose use is restricted to smaller patients due to the limited number of HSC present in the each unit. To enhance the blood reconstitution ability of a given number of HSC, present within e.g. one unit of UCB, can include developing methods to increase absolute HSC expansion, and/or achieve absolute HSC ...