Projects
Genomic Medicine: Translation of Whole Genome Analyses to Health Genomics KU Leuven
The translational Genomic Medicine IOF program is situated at the interface between clinical practice and strategic fundamental research and in a tight junction with the CME. The program was partitioned in three discrete lines of research and valorisation: A first line of research is focusing on novel approaches for postnatal diagnosis using massive parallel sequencing and whole genome sequencing. Both Prof. Vermeesch and Prof. Matthijs have ...
Whole genome reverse genetic predictions KU Leuven
A central challenge in genetics is to understand when and why mutations alter the phenotype of an organism. One original motivation behind sequencing the human genome eleven years ago was the goal of being able to predict an individual’s risk of disease from their genome sequence. However, this promise has not yet been fulfilled. Model organisms can be used to readdress this problem. In a model organism such as budding yeast we can make ...
Application of whole exome sequencing to identify the genetic defect in hereditary connective tissue disorders University of Antwerp
Integration of long read genome sequencing and single-cell multi-omics to identify genetic variation underlying Parkinson’s disease KU Leuven
In recent years, there have been major developments in ’omics technologies. Long read sequencing now produces highly accurate reads from single molecules with theoretically unlimited length. Long reads enable us to assemble whole human genomes de novo, study complex genomic regions and large structural variants, all of which are particularly difficult through conventional short read technologies. It also allows us to directly study DNA ...
Unravelling the genetic basis of cryptorchidism in pigs: experimental (design) optimisation and whole transcriptome analysis KU Leuven
The pig sector in Belgium is economically the most important subsector in agriculture with an annual production value of 1.5 billion euro (FOD Economie, 2015). Approximately 11.9 million pigs are being raised and slaughtered annually. An international estimate (Walters, 2016) reveals that on average 3.2% of the pigs suffers from a congenital defect, which would represent 380,000 individuals in Belgium each year. The economic loss caused by ...
Genome medicine for bleeding, thrombotic and platelet disorders KU Leuven
IDENTIFICATION AND VALIDATION OF DRUG-TARGET INTERACTIONS USING CRISPR/CAS-MEDIATED GENOME EDITING KU Leuven
Drug discovery and development are cornerstones of the pharmaceutical industry. However, these processes are difficult, time-consuming and costly. Many new drugs fail during clinical development due to insufficient demonstration of their clinical benefit and efficacy. One of the major reasons for this failing is the lack of robust understanding of a drug’s mechanism of action. In addition, phenotypic drug discovery is experiencing a revival ...
Sequencing DNA of museum specimens to uncover the genetic basis of rapid adaptation to heavy fishing. University of Antwerp
Sequencing Expertise Centre (Life Sciences) Ghent University
This Sequencing Expertise Centre allows UGent researchers to apply the newest sequenering technologies in their research in Life Sciences. The Centre provides access to state-of-the-art sequencing infrastructure and supports the entire process from sample preparation up to data analysis. This Centre bundles existing expertise at UGent, facilitates the introduction of innovative technologies and improves access and visibility.