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Researcher
Dirk Daelemans
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Oct 2013 → 31 Oct 2013 - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 2000 → Today
Projects
1 - 10 of 29
- Optimization of the anticancer drug target deconvolution processFrom31 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of proviral host factor combinations as drug targets for viruses with pandemic potentialFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Developing combinatorial immunotherapy for glioblastomaFrom7 Nov 2022 → TodayFunding: Foundations, funds and other with scientific goal
- Multiplex CRISPR screening to identify drug target combinations for antiviral therapyFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Uncovering kinase inhibitor resistance mechanisms via CRISPR-based gain-of-function mutagenesis.From12 Jul 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Identification of drug resistance mechanisms and acquired sensitivities in resistant cancer cells using genome-wide CRISPR-mediated screensFrom14 Sep 2020 → TodayFunding: FWO fellowships
- Combinatorial and personalized oncolytic virotherapy in the battle against glioblastomaFrom29 Aug 2020 → TodayFunding: FWO fellowships
- Breaking cancer drug resistance: exploring drug resistance mechanisms to exploit associated vulnerabilitiesFrom1 Jul 2020 → 30 Jun 2021Funding: BOF - postdoctoral mandates
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 155
- Synthesis and Biological Evaluation of Novel Amino and Amido Substituted Pentacyclic Benzimidazole Derivatives as Antiproliferative Agents(2024)
Authors: Dirk Daelemans
- New sugar-incorporated N-heterocyclic carbene precursors and their Ag(I) and Pd(II) complexes: Synthesis, characterization, and cytotoxicity studies(2024)
Authors: Dirk Daelemans, Wim Dehaen, Luc Van Meervelt
- Development of a novel class of Exportin 1 (XPO1/CRM1) inhibitors for anti-cancer therapy(2023)
Authors: Felien Reniers, Wim Dehaen, Dirk Daelemans
- 4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1(2023)
Authors: Dirk Daelemans
- Synthesis and Antiproliferative Activity of 2,6-Disubstituted Imidazo[4,5-b]pyridines Prepared by Suzuki Cross Coupling(2023)
Authors: Dirk Daelemans
- Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents(2023)
Authors: Eveline Vriens, Dries De Ruysscher, Sofie Dekimpe, Gert Steurs, Ahmed Shemy, Dirk Daelemans, Wim De Borggraeve, Eveline Lescrinier, Joleen Masschelein
- TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry(2023)
Authors: Jim Baggen, Maarten Jacquemyn, Els Vanstreels, Hendrik Jan Thibaut, Piet Maes, Dirk Daelemans
Pages: 3427 - + - Novel hydroxy- and amidino-substituted benzimidazoles and benzothiazoles as antibacterial and antiproliferative agents(2023)
Authors: Dirk Daelemans
Pages: 1251 - 1272 - Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents(2023)
Authors: Dirk Daelemans
Pages: 957 - 968 - Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation(2023)
Authors: Dirk Daelemans