Projects
Neuroendocrine pathways for the anabolic actions of androgens. KU Leuven
Neuromuscular alterations are a hallmark of sarcopenia although their underlying mechanisms remain elusive. The reduction in testosterone observed in these patients is a potential pathway implicated since androgens are suggested to preserve muscle innervation. In agreement, our earlier work in both global androgen receptor (AR) knockout (ARKO) and muscle cell-specific ARKO mice showed that the direct of androgens on male muscle are limited, ...
Development of an integrated strategy to characterize new lead compounds based on natural pro-drugs and their metabolites. University of Antwerp
The impact of reproductive axis hormones on changes in brain functional networks during healthy, accelerated and pathological aging (i.e. Alzheimer's disease). University of Antwerp
Synthesis of novel compounds with potential antiandrogen activity KU Leuven
Prostate cancer (PCa) is a major public health problem worldwide. It is estimated that it is the second common malignant neoplasm among men representing 13.5% of all the cancers diagnosed in men worldwide. Several therapies of metastatic PCa are based on the inhibition of the androgen receptor (AR) which is the key regulator of the prostate cancer cell growth.
The AR is activated by androgens like testosterone and 5α–dihydrotestosterone ...
Effects of brain-derived estrogens on behaviourally relevant auditory perception and song learning (memory) in the adult songbird brain. University of Antwerp
Liquid Chromatography tandem Mass Spectrometry for Routine Measurement of Steroid Hormones in Human Serum KU Leuven
Steroid hormones are physiologically important molecules that are regularly measured in human serum to aid in the diagnosis or follow-up of a variety of conditions. Routine steroid hormone testing is currently often performed on completely automated platforms within clinical laboratories. The reaction principles behind these methods are invariably antibody-based. Although these assays are easy-to-use, some fundamental weaknesses remain such ...
Evolutionary ecological perspectives on bird family life: A study into the genetic and phenotypic mechanisms of offspring begging. University of Antwerp
A quantitative genetic approach to study the mechanisms and functions of bird song. University of Antwerp
Towards the development of potent and selective inhibitors of hepatitis E virus. KU Leuven
Hepatitis A and E virus are the most prominent causes of acute viral hepatitis worldwide (chapter 1). Despite the availability of an effective vaccine for hepatitis A virus (HAV), it is widespread in developing countries and outbreaks still occur regularly in industrialized regions. Although most infections are asymptomatic, or have a mild clinical course, severe cases of hepatitis A may occur, especially in the elderly. The availability of ...