Closing the seronegative gap in rheumatoid arthritis diagnosis using B-cell receptor sequencing combined with mass spectrometric analysis of complementarity determining regions. KU Leuven
Rheumatoid arthritis (RA) is a chronic autoimmune disease, typically affecting joints but also showing manifestations in the whole body if left untreated. Diagnosis is based on anamnesis, clinical examination,
laboratory tests and imaging. Two biomarkers that are routinely tested in the clinic in patients suspected of having RA are considered to be specific for this disease, namely rheumatoid (RF) and anti-citrullinated protein ...