Researcher
Sarah Vergult
- Keywords:genetics, neurodevelopmental disorders, gene regulation, CRISPR/Cas9, 3D genome
- Disciplines:Analysis of next-generation sequence data, Clinical genetics and molecular diagnostics, Epigenetics, Molecular diagnostics, Genetics, Developmental neuroscience, Developmental biology, Stem cell biology
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2008 → 30 Sep 2018
Projects
1 - 10 of 20
- Unveiling the role of FOXG1 in neurodevelopment and disease: a comprehensive analysis using neural organoids, imaging and Single Cell SequencingFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Regulatory landscaping: Towards improved genetic diagnosis and therapy for SATB2-associated syndromeFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Steunfonds Marguerite-Marie Delacroix: A multi-omics approach to address neuronal development upon ZFHX4 deficiencyFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Incucyte S3: Comprehensive cellular phenotyping using high-throughput live cell imagingFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Regulatory landscaping: towards improved genetic diagnosis and therapy for SATB2-associated syndromeFrom1 Nov 2022 → TodayFunding: FWO fellowships
- IMAGIBRAINDD: IMAGIng-assisted human BRAIn organoid engineering for studying and treating NeuroDevelopmental DisordersFrom1 Oct 2022 → TodayFunding: BOF - projects
- 3D-RET: unlocking 3D genome architecture in human retina using C-technologiesFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- A multi-omics approach to address the role of ZFHX3 in neuronal developmentFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Steunfonds Marguerite-Marie Delacroix: Regulatory landscaping: towards improved genetic diagnosis and therapy for SATB2-associated syndrome (Lisa Hamerlinck)From1 Jan 2022 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- A multi-omics approach to address neuronal development upon ZFHX3 deficiencyFrom1 Dec 2020 → 31 Dec 2022Funding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 86
- A comprehensive comparison of different seeding densities and the use of microscaffolds to establish a reproducible protocol for unguided neural organoid differentiation(2023)
Authors: Nore Van Loon, Michael B Vaughan, Ruslan Dmitriev, Sarah Vergult
Number of pages: 1 - Structural variants disrupt a critical regulatory region downstream of FOXG1(2023)Volume: 31
Authors: Eva D'haene, Lies Vantomme, Björn Menten, Bert Callewaert, Elfride De Baere, Sarah Vergult
Pages: 28 - 28 - Comparative 3D genome analysis between neural retina and RPE reveals differential cis-regulatory interactions at retinal disease loci(2023)
Authors: Eva D'haene, Pedro Manuel Martinez-Garcia, Victor Lopez Soriano, Soraya Kalayanamontri, Alfredo Dueñas Rey, Lies Vantomme, Sarah Vergult, Ana Bastos Neto, José Luis Gomez-Skarmeta, Juan Ramon Martinez-Morales, et al.
Number of pages: 1 - Differential 3D genome topology shapes the regulatory landscapes of IRD genes in human neural retina and retinal pigment epithelium(2023)Volume: 64
Authors: Eva D'haene, Pedro Martinez-Garcia, Victor Lopez Soriano, Miriam Bauwens, Lies Vantomme, Sarah Vergult, Juan Martinez-Morales, Juan Tena, Elfride De Baere
Number of pages: 1 - Mapping the 3D genome of the human retina and its role in retinal disease(2023)Volume: 31
Authors: Eva D'haene, Victor Lopez Soriano, Lies Vantomme, Bernd Wissinger, Susanne Kohl, Sarah Vergult, Elfride De Baere
Pages: 57 - 57 - An optimized workflow for CRISPR/Cas9-mediated generation of indels and large deletions in induced pluripotent stem cells and neural stem cells(2022)
Authors: Lisa Hamerlinck, Maria del Rocio Pérez Baca, Lies Vantomme, Eva D'haene, Sarah Vergult
Pages: 38 - 38 - Mapping the 3D genome of the human retina and its role in retinal disease(2022)
Authors: Eva D'haene, Victor Lopez Soriano, Lies Vantomme, Bernd Wissinger, Susanne Kohl, Sarah Vergult, Elfride De Baere
Number of pages: 1 - Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models(2022)
Authors: Kiana Mohajeri, Rachita Yadav, Eva D'haene, Philip M. Boone, Serkan Erdin, Dadi Gao, Mariana Moyses-Oliveira, Riya Bhavsar, Benjamin B. Currall, Kathryn O'Keefe, et al.
Pages: 2049 - 2067 - A novel neurodevelopmental syndrome caused by loss-of-function of the Zinc Finger Homeobox 3 (ZFHX3) gene(2022)
Authors: Maria del Rocio Pérez Baca, Eva Jacobs, Lies Vantomme, Pontus LeBlanc, Elke Bogaert, Annelies Dheedene, Laurenz De Cock, Bart Dermaut, Aidin Foroutan, Jennifer Kerkhof, et al.
Number of pages: 1 - Expanding the phenotype of B3GALNT2-related disorders(2022)
Authors: Erika D'haenens, Sarah Vergult, Annelies Dheedene, R. Frank Kooy, Bert Callewaert