The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free) KU Leuven
Steroid hormones such as testosterone or vitamin D are vital for
human physiology. In circulation, steroid hormones bind to specific
binding proteins and albumin, with only a small fraction circulating
freely. The ‘free hormone hypothesis’ suggests that this free fraction
is responsible for biological activity. Though experimental and clinical
data support this, routinely available methods measure total hormone ...