Mapping the impact of post-translational modifications on protein aggregation. KU Leuven
A diverse group of principal widespread diseases, including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), type II diabetes mellitus and many others, shares a single common feature referring to the constant build-up of protein deposits, which causes various symptoms of growing severity (inflammation, tissue degeneration and full organ disfunction). Aberrant aggregation is promoted by short hydrophobic segments, located within ...