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Researcher
Joost Schymkowitz
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Proteins, Bioinformatics of disease, Structural bioinformatics and computational proteomics, Synthetic biology, Proteomics
Affiliations
- Switch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Switch Laboratory (VIB-KU Leuven) (Division)
Member
From1 Jan 2011 → Today - Department of Cellular and Molecular Medicine (Department)
Member
From15 Sep 2010 → 31 Dec 2010
Infrastructure
1 - 1 of 1
- When size matters: a platform to study molecular interactions and multimerisation (Consortium coordinator)
Projects
1 - 10 of 57
- Deciphering TDP-43 molecular signatures in LATE: towards a multitarget diagnosisFrom1 Oct 2024 → TodayFunding: FWO junior postdoctoral fellowship
- Uncovering the implications of N-glycosylation and protein aggregation in human diseaseFrom1 Oct 2024 → TodayFunding: BOF - postdoctoral mandates
- Mechanisms of Amyloid Co-Pathologies in Neurodegenerative DiseasesFrom23 Sep 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The Hidden Biology of Inclusion BodiesFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- New molecular tools for diagnostic and treatment of systemic amyloidosisFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Heterotypic aggregation of Aβ42 with disease-relevant proteins in Alzheimer’s diseaseFrom1 Oct 2023 → 1 Apr 2024Funding: FWO junior postdoctoral fellowship
- Structural and morphological studies of heterotypic amyloid fibrilsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Cotranslational protein folding and aggregationFrom4 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigation of Heterotypic Interactions of TDP-43 Aggregation in NeurodegenerationFrom11 Apr 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 164
- Steering proteins toward their native fold during translation(2024)
Authors: Ramon Duran Romaña, Joost Schymkowitz, Frederic Rousseau
- A core proteome profile unites mouse models and patients in Alzheimer disease(2024)
Authors: Grigoria Tsaka, Frederic Rousseau, Joost Schymkowitz
- An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets(2024)
Authors: Wouter Duverger, Laleh Khodaparast, Ladan Khodaparast, Frederic Rousseau, Joost Schymkowitz
- Mechanistic insights into the adaptive evolvability of spore heat resistance in Bacillus cereus sensu lato(2024)
Authors: Sadhana Khanal, Wouter Duverger, Joost Schymkowitz, Frederic Rousseau, Chris Michiels, Abram Aertsen
- Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease(2024)
Authors: Xiaojuan YANG, Joris Winderickx, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Wim Annaert
- CORDAX web server: an online platform for the prediction and 3D visualization of aggregation motifs in protein sequences(2024)
Authors: Frederic Rousseau, Joost Schymkowitz
- Integrating physics in deep learning algorithms: a force field as a PyTorch module(2024)
Authors: Gabriele Orlando, Joost Schymkowitz, Frederic Rousseau
- CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods(2024)
Authors: Frederic Rousseau, Joost Schymkowitz
- Local structural preferences in shaping tau amyloid polymorphism(2024)
Authors: Grigoria Tsaka, Rodrigo Gallardo, Dietmar Thal, Frederic Rousseau, Joost Schymkowitz
- N-glycosylation as a eukaryotic protective mechanism against protein aggregation(2024)
Authors: Bert Houben, Matthias De Vleeschouwer, Matthew Wilson, Gert Matthijs, Joost Schymkowitz, Frederic Rousseau
Patents
1 - 10 of 10
- Beta-lactamase inhibitors (Inventor)
- Molecules targeting ras protein (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Carbon dioxide generation (Inventor)
- Molecules targeting ras protein (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Means and methods for the prediction of amyloid core sequences (Inventor)
- Means and methods for the treatment of pathological aggregation (Inventor)