Projects
Single cell T-cell receptor and Expression Grouped Ontologies to develop a data-driven tool to identify T-cell immunity groups within a micro-environment and characterize the complex interplay of lymphocyte subtypes contributing to an immune response University of Antwerp
MulTplex project: Development of a combinatorial multi-epitope T-cell receptor (TCR), non-signaling chimeric antigen receptor (NSCAR) and immunosuppressive immune checkpoint (IICP)-disrupted adoptive T-cell therapy against leukemia. University of Antwerp
PrioriTCR - Prioritization of T-cell receptors for development of T-cell therapy using an immunoinformatics approach. University of Antwerp
ETV6 : the Achilles' heel of early T-cell progenitor T-cell acute lymphoblastic leukemia Ghent University
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric and 25% of adult ALL cases and was originally identified as a highly aggressive tumor associated with poor prognosis. Recent studies have identified a subset of T-ALLs whose transcriptional programs resemble those of immature early T-cell progenitors (ETP) and hematopoietic stem cells. Importantly, these so-called ETP-ALLs have strong clinical relevance since they are ...
The function of PHF6 in normal T-cell development and T-cell acute lymphoblastic leukemia Ghent University
T-ALL results from the malignant transformation of thymocytes and mainly affects children. Recently, PHF6 was identified as a novel tumor suppressor gene in T-ALL at the Center of Medical Genetics Ghent. The aim of this project is to investigate the role of PHF6 in the development of normal T-cells and T-ALL and to unravel transcriptional networks regulated by PHF6
The role of PHF6 in normal T-cell development and T-cell acute lymphoblastic leukemia Ghent University
T-ALL results from the malignant transformation of thymocytes and mainly affects children. Recently, PHF6 was identified as a novel tumor suppressor gene in T-ALL at the Center of Medical Genetics Ghent. The aim of this project is to investigate the role of PHF6 in the development of normal T-cells and T-ALL and to unravel transcriptional networks regulated by PHF6
The role of PHF6 in normal T-cell development and T-cell acute lymphoblastic leukemia Ghent University
T-ALL results from the malignant transformation of thymocytes and mainly affects children. Recently, PHF6 was identified as a novel tumor suppressor gene in T-ALL at the Center of Medical Genetics Ghent. The aim of this project is to investigate the role of PHF6 in the development of normal T-cells and T-ALL and to unravel transcriptional networks regulated by PHF6.
Unraveling the role of PHF6 in normal T-cell development and T-cell acute leukemia Ghent University
T-ALL results from malignant transformation of thymocytes. Although treatment outcome has improved, many factors contributing to T-ALL development remain unknown. Recently, PHF6 was identified as a novel tumor suppressor gene in the pathogenesis of T-ALL at our lab. The aim of this project is to investigate the cellular function of PHF6 and its role in normal T-cell and T-ALL development
ETV6: the AchillesU+2019 heel of early T-cell progenitor T-cell acute lymphoblastic leukemia. Ghent University
Recently, we identified ETV6 as a gene, recurrently implicated in a specific leukemia subclass (ETP-T-ALL). Although ETV6 is a well-known leukemia gene, the ways in which it contributes to leukemia remain unexplored. In this project, we will study how ETV6 functions in normal T-cell development and T-ALL. This project will lead to groundbreaking insights in ETP-T-ALL development and progression.