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Organisation

Allergy and Clinical Immunology Research Group

Division

Lifecycle:1 Jan 1995  →  Today
Organisation profile:

Laboratory of clinical immunology

1. Research on the pathogenesis and etiology of primary immunodeficiencies

2. Research on the cause and diagnosis of anaphylaxis

3. STUDIES ON HELPER SIGNALS REQUIRED FOR T CELL ACTIVATION: Regulation of cytokine production and of cytotoxicity upon T cell activation. Role of B7-CD28 interaction and of cytokines produced by antigen-presenting cells (IL-1ß, IL-6, IL-12, IL-15) for T cell activation. Effect of blocking CD28 and/or CD40 in autoimmune diseases (animal models). Anergy induction via blocking of helper signals. 2. STUDIES ON PHAGOCYTE Fc RECEPTORS: Variants of Fc receptors and their specific function. Changes in Fc receptor expression during activation and/or differentiation of phagocytic cells. Genetic polymorphism. 3. DIFFERENTIATION AND ACTIVATION OF MONOCYTES

Keywords:Allergy, T-lymphocytes, TH1/TH2 balance, Anergy induction, Cytokines, Immonology, Accessory signaling, anaphylaxis, primary immunodeficiency
Disciplines:Immunology, Laboratory medicine