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Unraveling the role of PHF6 in normal T-cell development and T-cell acute leukemia (01P14010)

T-ALL results from malignant transformation of thymocytes. Although treatment outcome has improved, many factors contributing to T-ALL development remain unknown. Recently, PHF6 was identified as a novel tumor suppressor gene in the pathogenesis of T-ALL at our lab. The aim of this project is to investigate the cellular function of PHF6 and its role in normal T-cell and T-ALL development

Date:1 Oct 2010  →  30 Nov 2014
Keywords:T-ALL, T-cells, PHF6, leukemia
Disciplines:Morphological sciences, Medical systems biology, Systems biology, Oncology, Hematology, Molecular and cell biology, Laboratory medicine