Projects
IOF POC Project SYNALI : Development and application of a Synthetic Nanobody Library Vrije Universiteit Brussel
Ecclesiastical Assemblies and the Transformation of Post-CarolingianSociety. Councils and synods as a Forum for Negotiation betweenKings, Church Leaders and Secular Magnates (Francia, c. 875-c. 1075) KU Leuven
A Microelectrode Platform for Recording Neural Activity Through Molecularly Defined Synaptic Connections KU Leuven
An immunofluorescence toolbox for the assessment of synaptic pathology. University of Antwerp
Resilience and vulnerability in the cellular phase of Alzheimer’s disease. KU Leuven
This project proposes an integrative approach to assess how the different pathological mechanisms of AD are linked to each other and how genetic risk of AD underlays resilience or vulnerability. While the classical neuron-centric view on AD pathogenesis sees amyloid peptides as triggers of synaptic dysfunction and Tau pathology as the executor of neurodegeneration, it is now clear that other cell types also react to amyloid plaques and that ...
Assessment of synaptic density and mHTT aggregates in post-mortem human brain tissue of patients with Huntington's Disease. University of Antwerp
Synaptic dysfunction in Parkinson’s disease and neurodegeneration. KU Leuven
Parkinson’s disease is an incurable neurodegenerative, lethal movement disorder affecting ~10 million people. Familial disease is caused by mutations in >20 genes and these map to a limited number of diverse molecular pathways. Using new and extensive collections of fruit flies and iPS cells we are studying the mutations in these genes that cause disease, with the ultimate goal to understand the underlying pathogenic pathways. In addition, ...
Functional role of Protocadherin10 in murine brain development KU Leuven
Autism Spectrum Disorders (ASDs) are a group of debilitating neurodevelopmental disorders that affect millions of patients world-wide. ASD is hypothesized to arise from a complex interplay between genetic and environmental factors that impact the structure and function of the developing brain. A potential cause of the disease pathophysiology is a disrupted excitation/inhibition balance in the central nervous system stemming from abnormal ...