Projects
Synthesis and (pre)clinical evaluation of PET radioligands for in vivo visualization of phosphodiesterase 10, an enzyme involved in neurological and psychiatric disorders. KU Leuven
Data-driven brain and heart PET imaging of awake rodents. University of Antwerp
Motion compensation for PET in TOF-PET/CT and TOF-PET/MR brain imaging KU Leuven
Deep Learning for enabling cost-effective high-throughput Total-Body PET Ghent University
Since the advent of Total-Body PET (TB-PET), sub-one-minute acquisitions at reasonable dose levels and very good image quality are within reach. However, the high unit price and maintenance cost, which is about 3-4 times higher than conventional PET-CT, coupled with limited achievable practical patient throughput significantly impedes implementation into clinical routine. The MEDISIP research group proposes a novel TB-PET system concept, the ...
PET imaging of the mGluR5 receptor in addiction: its role in deficient corticostriatal control and glutamatergic modulation of dopaminergic neurotransmission KU Leuven
Addiction is a complex brain disorder, leading to a compulsive obsession to use a substance despite serious detrimental consequences. Apart from a dysfunctional reward system, reduced inhibitory corticostriatal control in drug-seeking and drug-taking1 and vulnerability to addiction2 has been emphasized. Genetic, developmental, and environmental factors are major contributors to addiction risk, but the neurobiological processes that underlie ...
BEyOND: Brain pEt to Overcome Neurodegenerative Diseases. KU Leuven
BEyOND trains ESR fellows in innovative approaches to develop quantitative brain PET imaging for better patient care and accelerated drug development for neurodegenerative diseases. Brain disorders are a major public health problem in Europe, and pharmaceutical drugs are the predominant therapeutic approach. In order to manage the constantly increasing healthcare and drug development costs, there is an urgent need for next-generation ...