Researcher
Leonie Wyffels
- Keywords:Pharmacy and pharmacology
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Medicinal products, Pharmaceutical analysis and quality assurance, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Other medical and health sciences
Affiliations
- Molecular Imaging and Radiology (MIRA) (Research group)
Member
From1 Jan 2019 → 30 Sep 2019 - Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO) (Research group)
Member
From1 Feb 2012 → 31 Dec 2018
Projects
1 - 7 of 7
- Development of novel TCO probes for pretargeted intracellular PET imaging.From1 Oct 2018 → 31 Oct 2019Funding: BOF - Other initiatives
- Development of novel cell death PET imaging probes for early treatment response assessment.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Development of a caspase-3 selective activity-based probe for PET imaging of apoptosisFrom1 Apr 2016 → 31 Mar 2017Funding: BOF - Other initiatives
- Development of 18F-poly(2-oxazoline)-duramycin and 18Fpoly( 2-oxazoline)-RGD as radiotracers for in vivo imaging of tumor environment.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Poxylation as next generation Pegylation.From1 Feb 2013 → 31 Jan 2014Funding: SBO (Strategic basic research)
- PET and SPECT imaging of protease activity by activitybased probes.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Immuno-positron emission tomography as a potential biomarker for diagnosis and treatment in Alzheimer disease.From1 Apr 2012 → 31 Mar 2014Funding: IWT / VLAIO - indirect funding by business world
Publications
1 - 10 of 75
- Development of caspase-3-selective activity-based probes for PET imaging of apoptosis(2024)
Authors: Louis Lauwerys, Lucas Beroske, Angelo Solania, Christel Vangestel, Alan Miranda Menchaca, Nele Van Giel, Karuna Adhikari, Anne-Marie Lambeir, Leonie Wyffels, Dennis Wolan, et al.
Pages: 1 - 26 - First-in-human study of a novel cell death tracer $\left[^{99m}Tc\right]Tc-Duramycin$: safety, biodistribution and radiation dosimetry in healthy volunteers(2023)
Authors: Taco Metelerkamp Cappenberg, Stijn De Schepper, Christel Vangestel, Leonie Wyffels, Tim Van den Wyngaert, Jeffrey Mattis, Brian Gray, Koon Pak, Sigrid Stroobants, Filipe Elvas
Pages: 1 - 15 - Synaptic vesicle glycoprotein 2A is affected in the CNS of Huntington’s Disease mice and post-mortem human HD brain(2022)
Authors: Daniele Bertoglio, Jeroen Verhaeghe, Leonie Wyffels, Alan Miranda Menchaca, Sigrid Stroobants, Ladislav Mrzljak, Celia Dominguez, Mette Skinbjerg, Jonathan Bard, Longbin Liu, et al.
Pages: 942 - 947 - Longitudinal preclinical evaluation of the novel radioligand [¹¹C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington's disease(2022)
Authors: Daniele Bertoglio, Jeroen Verhaeghe, Alan Miranda Menchaca, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Vinod Khetarpal, Mette Skinbjerg, Longbin Liu, Celia Dominguez, et al.
Pages: 1166 - 1175 - Kinetic modelling and test-retest reproducibility for the dopamine D₁R radioligand [¹¹C]SCH23390 in healthy and diseased mice(2021)
Authors: Daniele Bertoglio, Jeroen Verhaeghe, Alan Miranda Menchaca, Leonie Wyffels, Sigrid Stroobants, Celia Dominguez, Ignacio Munoz-Sanjuan, Mette Skinbjerg, Longbin Liu, Steven Staelens
Pages: 208 - 219 - TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy(2021)
Authors: Daniele Bertoglio, Halima Amhaoul, Joery Goossens, Idrish Ali, Elisabeth Jonckers, Tom Bijnens, Matteo Siano, Leonie Wyffels, Jeroen Verhaeghe, Annemie Van Der Linden, et al.
- Elevated type 1 metabotropic glutamate receptor availability in a mouse model of Huntington’s disease: a longitudinal PET study(2020)
Authors: Daniele Bertoglio, Jeroen Verhaeghe, Špela Korat, Alan Miranda Menchaca, Klaudia Cybulska, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Celia Dominguez, Mette Skinbjerg, et al.
Pages: 2038 - 2047 - [¹⁸F]ZCDD083: a PFKFB3-targeted PET tracer for atherosclerotic plaque imaging(2020)
Authors: Carlo De Dominicis, Paola Perrotta, Sergio Dall'Angelo, Leonie Wyffels, Steven Staelens, Guido De Meyer, Matteo Zanda
Pages: 933 - 939 - Preclinical evaluation of a novel ¹⁸F-labeled dTCO-amide derivative for bioorthogonal pretargeted positron emission tomography imaging(2020)
Authors: Eduardo Ruivo, Filipe Elvas, Karuna Adhikari, Christel Vangestel, Glenn Van Haesendonck, Filip Lemière, Steven Staelens, Sigrid Stroobants, Pieter Van Der Veken, Leonie Wyffels, et al.
Pages: 4449 - 4456 - Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice(2020)
Authors: Dorien Glorie, Jeroen Verhaeghe, Alan Miranda Menchaca, Istvan Kertesz, Leonie Wyffels, Sigrid Stroobants, Steven Staelens