Projects
Underlying mechanisms of neuroplasticity and motor control: Modulation of neuroplasticity in the development of novel rehabilitation strategies in neurodegenerative diseases Hasselt University
BEyOND: Brain pEt to Overcome Neurodegenerative Diseases. KU Leuven
BEyOND trains ESR fellows in innovative approaches to develop quantitative brain PET imaging for better patient care and accelerated drug development for neurodegenerative diseases. Brain disorders are a major public health problem in Europe, and pharmaceutical drugs are the predominant therapeutic approach. In order to manage the constantly increasing healthcare and drug development costs, there is an urgent need for next-generation ...
Blocking immune cell migration into the brain: a targeted therapy for autoimmune and neurodegenerative diseases Hasselt University
Walking the lines of engineering, biology and medicine: Creating 3D human neuromuscular junctions to evaluate novel therapies for neurodegenerative diseases KU Leuven
Novel protein markers as early diagnostic or prognostic markers in neuroinflammatory and neurodegenerative diseases KU Leuven
PET/MR imaging and quantification of neuroinflammation, tau and synaptic density in neurodegenerative diseases KU Leuven
For brain PET imaging with abundant target expression throughout the whole brain or with changing target density depending on pathology or disease stage, arterial blood sampling is mandatory for accurate PET quantification. While these PET imaging procedures can be highly relevant for clinical use or drug development, the invasive nature of arterial cannulation has a substantial impact on patient comfort while the complexity, logistics and ...
Microtubules in the pathogenesis of neurodegenerative diseases. KU Leuven
In a second phase we will study the function of Elp3 with regards to ...
GVD-necroptosis as a driving process of neurodegeneration in Alzheimer’s disease KU Leuven
Accumulation of misfolded proteins and the associated neuronal dysfunction and loss are considered as most important hallmarks of neurodegenerative diseases including Alzheimer’s disease (AD). Specific for AD is the extensive deposition of extracellular amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). These changes are associated with marked neuro-inflammation and cerebral atrophy. While neuronal cell death is very ...