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Researcher
Ludo Van Den Bosch
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Affiliations
- Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Responsible
From1 Oct 2018 → Today - Van Den Bosch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2012 → Today - Research Group Experimental Neurology (Division)
Member
From1 Oct 2002 → 31 Dec 2011
Projects
1 - 10 of 58
- Investigating fatty acid toxicity in amyotrophic lateral sclerosisFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- Investigating the therapeutic potential of HDAC6 inhibition in amyotrophic lateral sclerosis (ALS) using human induced pluripotent stem cells (iPSCs).From1 May 2023 → TodayFunding: Other federal public and semi-governmental institutions
- FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanismsFrom19 Apr 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Creating iPSC-derived 3D human neuromuscular junctions to investigate amyotrophic lateral sclerosis (ALS)From15 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating mechanisms of RNA misprocessing in Amyotrophic Lateral SclerosisFrom8 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Determination and investigation of the therapeutic targets of HDAC6 inhibition in amyotrophic lateral sclerosis (ALS)From1 Jan 2023 → TodayFunding: FWO research project
- Creation of a humanized mouse model for demyelinating peripheral neuropathies as a platform for therapeutic testing.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Investigating the role of DNA damage and repair in the selective motor neuron death during amyotrophic lateral sclerosis (ALS)From15 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS): cell death pathways and/or aberrant communication between cell body and neuromuscular junctionsFrom1 Oct 2022 → TodayFunding: BOF - projects
- Investigating the role of cilia dysfunction in Amyotrophic Lateral SclerosisFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 217
- Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit(2023)
Authors: Ludo Van Den Bosch
Pages: 1821 - 1843 - A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons(2023)
Authors: Jimmy Beckers, Dietmar Thal, Ludo Van Den Bosch, Philip Van Damme
- Abnormal energy metabolism in ALS: a key player?(2023)
Authors: Ludo Van Den Bosch
Pages: 338 - 345 - Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A(2023)
Authors: Ludo Van Den Bosch
Pages: 2885 - 2896 - Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2a-dependent ISR in C9ORF72 FTD/ALS(2023)
Authors: Ludo Van Den Bosch
- Human Neuromuscular Junction on a Chip: Impact of Amniotic Fluid Stem Cell Extracellular Vesicles on Muscle Atrophy and NMJ Integrity(2023)
Authors: Katarina Dittlau, Laura Yedigaryan, Ludo Van Den Bosch, Maurilio Sampaolesi
- FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and mechanisms(2023)
Authors: Lisanne Terrie, Pegah Masrori, Philip Van Damme, Lieven Thorrez, Ludo Van Den Bosch
- F/YGG-motif is an intrinsically disordered nucleic-acid binding motif(2022)
Authors: Ludo Van Den Bosch
Pages: 622 - 635 - Utilising CRISPR-Cas13 systems to target frontotemporal dementia and amyotrophic lateral sclerosis-causing C9orf72 repeat expansion-containing RNA(2022)
Authors: Ludo Van Den Bosch
Pages: A8 - A9 - HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS(2022)
Authors: Elke Braems, Valérie Bercier, Evelien Van Schoor, Jimmy Beckers, Ilse Geudens, Dietmar Thal, Philip Van Damme, Bart Swinnen, Ludo Van Den Bosch
Pages: 465 - 488
Patents
1 - 4 of 4