Researcher
Ludo Van Den Bosch
- Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Affiliations
- Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Responsible
From1 Oct 2018 → Today - Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2012 → Today
Projects
1 - 10 of 48
- Mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS): cell death pathways and/or aberrant communication between cell body and neuromuscular junctionsFrom1 Oct 2022 → TodayFunding: BOF - projects
- Danio rerio: a “humanized” in vivo model for the study of non-cell autonomous mechanisms in ALSFrom10 Jan 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Unravelling the mechanism(s) responsible for the therapeutic effect of histone deacetylase 6 (HDAC6) inhibition in amyotrophic lateral sclerosis (ALS)From1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of therapies targeting lipid metabolism and myelination for Charcot-Marie-Tooth disease type 1A using patient-derived Schwann cellsFrom18 Jan 2021 → TodayFunding: FWO fellowships
- ALS-fellowship: Understanding the role of FUS in ALS through assessment and modulation of its phase separation behaviour in vivo.From1 Nov 2020 → TodayFunding: FWO junior postdoctoral fellowship
- Atomic Force Microscopy Enhanced Spectroscopy to Study Strains and Seeding of Amyloids In SituFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Unravelling the protective effect of RNA-binding proteins on the RNA toxicity in amyotrophic lateral sclerosis (ALS)From1 Jan 2020 → TodayFunding: FWO research project
- Targeting oxidative stress and metabolic dysfunctionin amyotrophic lateral sclerosis.From1 Oct 2019 → TodayFunding: FWO fellowships
- Determining the role of KIF5A in amyotrophic lateral sclerosis (ALS) pathogenesisFrom1 Oct 2019 → TodayFunding: FWO fellowships
- Investigating mitochondrial transport in sporadic ALSFrom6 Sep 2019 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 180
- Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules.(2022)
Authors: Thomas Vercruysse, Philip Van Damme, Dirk Daelemans, Ludo Van Den Bosch
Pages: 1057 - ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function(2022)
Authors: Valérie Bercier, Ludo Van Den Bosch
Number of pages: 28 - Investigating the role of mutant TDP-43-ALS using human iPSC-derived motor neurons(2022)
Authors: Raheem Fazal, Philip Van Damme, Ludo Van Den Bosch, Catherine Verfaillie
- Frontotemporal Lobar Degeneration Case with an N-Terminal TUBA4A Mutation Exhibits Reduced TUBA4A Levels in the Brain and TDP-43 Pathology(2022)
Authors: Evelien Van Schoor, Mathieu Vandenbulcke, Valérie Bercier, Rik Vandenberghe, Philip Van Damme, Ludo Van Den Bosch, Dietmar Rudolf Thal
Number of pages: 13 - Transcription factor-based differentiation of pluripotent stem cells to investigate the role of glial cells in FUS-linked ALS(2021)
Authors: Katrien Neyrinck, Catherine Verfaillie, Ludo Van Den Bosch
- Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis(2021)
Authors: Elisabeth Rossaert, Philip Van Damme, Ludo Van Den Bosch
Number of pages: 21 - Axonal transport defects in C9orf72 ALS/FTD: the role of dipeptide repeat proteins(2021)
Authors: Laura Fumagalli, Philip Van Damme, Ludo Van Den Bosch, Catherine Verfaillie
- Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition(2021)
Authors: Katarina Stoklund Dittlau, Laura Fumagalli, Elisabeth Rossaert, Maurilio Sampaolesi, Philip Van Damme, Ludo Van Den Bosch
Pages: 2213 - 2227Number of pages: 15 - Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices(2021)
Authors: Katarina Stoklund Dittlau, Elisabeth Rossaert, Maurilio Sampaolesi, Philip Van Damme, Ludo Van Den Bosch
Number of pages: 25 - Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS(2021)
Authors: Ludo Van Den Bosch
Number of pages: 12