This project will focus on peroxisomal functions and their involvement in inflammatory processes in the
context of chronic rhinosinusitis. The emphasis on the investigations will be put on the peroxisomes of mast
cells. The experiments will be done on human ex vivo nasal tissue and murine models.
Exploring the role of a novel mast cell activation pathway in IBD and IBS models. University of Antwerp
Mast cell activation tests (MAT): from an innovative diagnostic to the expansion of a service facility. University of Antwerp
Using molecular signaling profile in white blood cells measured by highly-sensitive mass spectrometry (MS)-based proteomics in the differential diagnosis between major depressive disorder and bipolar disorder. University of Antwerp
Role of dendritic cells in Th1/Th17-mediated immune diseases. University of Antwerp
Induction of IgA2 class switching in human Ige+B cells as theraphy for allergic disease Ghent University
Abstract (max. 60 woorden): IgE plays a central role in allergy by activating mast cells and facilitating allergen presentation to Th2 lympghocytes. Accumulating evidence suggests that IgA plays a protective role in allergy by antagonizing the effects of IgE. Therefore using three proven IgA promoting regimens: IL-21+TGFB1, cholera toxin B (CTB) and Lactococci engineerd to express allergen and CTB
Mastocytosis and Hymenoptera Venom Allergy - Unraveling the enigmatic link between two unusual diseases KU Leuven
Mastocytosis (Ms) is a rare and heterogenous myeloproliferative disorder affecting 2 in 10,000. It affects all age groups and exists in many different forms, ranging from a benign skin rash to agressive haematological neoplasms. Because of its rarity and complexity, much concerning pathogenesis, diagnosis, treatment and prognosis remains unknown. In recent years, the association between Ms and hymenoptera venom allergy (HVA) has been ...