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Heiko De Schepper

  • Research interest:1. During my medical training, I participated in several experiments focusing on the characterization of neurotransmitters in motility of the mouse small intestine. We found evidence for a role of ATP in inhibitory neurotransmission and of all three tachykinin receptor subtypes in excitatory neurotransmission. a. De Schepper HU, De Winter BY, Seerden TC, Herman AG, Pelckmans PA, De Man JG. The role of tachykinins in circular muscle contractility of the murine ileum: a functional investigation. Auton Neurosci. 2006 ;126-127: 273-6. b. De Schepper HU, De Winter BY, Seerden TC, Herman AG, Pelckmans PA, De Man JG. Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum. Regul Pept. 2005; 130: 105-15.2. During my PhD I performed both functional and electrophysiological experiments detailing the effects of acute TNBS colitis in rats on gastrointestinal motility and sensitivity. The main contribution of this work was to identify TRPV1 receptors as potential therapeutic targets in visceral pain. a. Vermeulen W, De Man JG, De Schepper HU, Bult H, Moreels TG, Pelckmans PA, De Winter BY. Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats. Eur J Pharmacol. 2013; 698: 404-12.b. De Winter BY, Bredenoord AJ, Van Nassauw L, De Man JG, De Schepper HU, Timmermans JP, Pelckmans PA. Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: role of CGRP and TRPV1 receptors. Eur J Pharmacol. 2009; 615:177-84. c. De Schepper HU, De Winter BY, Van Nassauw L, Timmermans JP, Herman AG, Pelckmans PA, De Man JG. TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats. J Physiol. 2008; 586: 5247-58. d. De Man JG, Boeckx S, Anguille S, de Winter BY, De Schepper HU, Herman AG, Pelckmans PA. Functional study on TRPV1-mediated signalling in the mouse small intestine: involvement of tachykinin receptors. Neurogastroenterol Motil. 2008; 20: 546-56.e. De Schepper HU, De Man JG, Ruyssers NE, Deiteren A, Van Nassauw L, Timmermans JP, Martinet W, Herman AG, Pelckmans PA, De Winter BY. TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats. Am J Physiol Gastrointest Liver Physiol. 2008 ; 294: G245-53. f. De Schepper HU, De Man JG, Van Nassauw L, Timmermans JP, Herman AG, Pelckmans PA, De Winter BY. Acute distal colitis impairs gastric emptying in rats via an extrinsic neuronal reflex pathway involving the pelvic nerve. Gut. 2007; 56: 195-202.3. During my fellowship at the motility department of the AMC Amsterdam, I performed 2 technical studies on the performance of high resolution esophageal manometry in detecting esophageal motility disorders. a. De Schepper HU, Ponds FA, Oors JM, Smout AJ, Bredenoord AJ. Distal esophageal spasm and the Chicago classification: is timing everything? Neurogastroenterol Motil. 2016; 28: 260-5.b. De Schepper HU, Kessing BF, Weijenborg PW, Oors JM, Smout AJ, Bredenoord AJ. Impact of spatial resolution on results of esophageal high-resolution manometry. Neurogastroenterol Motil. 2014; 26: 922-8.4. As a senior resident in the University Hospital of Antwerp, I have established a gastrointestinal motility clinic with a florid multidisciplinary pelvic floor unit. Several clinical research projects are currently ongoing, of which the first has now been published, concentrating on the manometric characterization of patients with fecal incontinence. a. Somers M, Peleman C, Van Malderen K, Verlinden W, Francque S, De Schepper H. Manometric and ultrasonographic characteristics of patients with coexisting fecal incontinence and constipation. Acta Gastroenterol Belgica.
  • Disciplines:Diagnostics, Gastro-enterology and hepatology, Immunology, Laboratory medicine, Microbiology, Molecular and cell biology, Neurosciences, Physiology, Nutrition and dietetics
  • Research techniques:Clinical manometry (esophagus, anorectal, colon)
  • Users of research expertise:researchers with special interest in neurogastroenterologycommercial pharmaceutical companies developing compounds in neurogastroenterology