Projects
Monogenic immune disorders in adults: from Mendelian inheritance to somatic mosaicism KU Leuven
Disease manifestations of monogenic immune disorders, such as immunodeficiency, autoinflammation or autoimmunity, can be delayed until adulthood and this is mediated through various genetic mechanisms, extending beyond Mendelian inheritance. Despite the discovery of multiple genetic causes in the last decade, most patients lack a molecular diagnosis preventing personalized care. Furthermore, while the role of pathogenic somatic variants is ...
Fatty acid metabolism in control of the phenotype of foamy phagocytes in multiple sclerosis. Hasselt University
Oncostatin M-induced astrocytic TIMP-1: the key to central nervous system lesion repair. Hasselt University
Development of a technology platform for next-generation cytometry KU Leuven
Flow cytometry is a technique which has revolutionized cell-based scientific disciplines, including immunology, cancer and stem cell biology. The essence of flow cytometry is the ability to take a large mixed population of cells, narrow them down to a fluid stream that is only a single cell in diameter, and then read multiple parameters from that cell. This process allows us to distinguish different cell types apart from each other and to ...
Next-generation, multi-technology immune-monitoring and easy-access spectral flow cytometry KU Leuven
Flow cytometry represents an essential technology in all
domains of fundamental, translational and clinical
biomedical research. At the KU Leuven, flow cytometric
services are centralized at the KU Leuven Flow and Mass
Cytometry core facility (KUL-FMC) and shaped by the needs
of its users. However, beyond life-time mid-range
cytometers threaten the research continuity. To warrant an
uninterrupted transition ...
"BD FACS Verse" Flow Cytometer. KU Leuven
Technology-supported innovative rehabilitation Hasselt University
Clinical, immunological and genetic unravelling of severe isolated central nervous system disorders in children. KU Leuven
Neuroimmune disorders in previously healthy children often have a
detrimental outcome. Unfortunately, an integrated view on the
pathophysiology and genetic causes, combining neurological and
immunological insight, is lacking. However increased knowledge of
the molecular pathogenesis could significantly improve the
management of these diseases. Several inborn errors of immunity
(IEI) underlie ...