The role of adipose tissue hypoxia in obesity and obstructive sleep apnea. University of Antwerp
Skeletal muscle is essential to life as it provides the mechanical power for locomotion and breathing. In our aging population, loss of muscle mass due to long- term inactivity is a major cause of morbidity and mortality. It is also a critical component of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), and although the role of muscle in ALS is debated improving muscle functioning prolongs survival. Thus, preventing ...
Targeting Polo-like kinase 1 for treatment of NSCLC patients: focus on the induction of cellular senescence, the TP53 status and hypoxia. University of Antwerp
Characterisation of epigenetic control of cancer-inflammation by jumonji histone demethylases during hypoxia University of Antwerp
Improving cancer immunotherapy outcome by targeting hypoxia. University of Antwerp
The role of biomechanical factors and hypoxia in the induction of chronic tendinitis in spondyloarthropathy. Ghent University
This research project aims to analyze the consequences of frequently occurring stress conditions in joint homeostasis and how these may contribute to chronicity of inflammation in arthritic joint diseases, notably Spondyloarthritis (SpA). The current project therefore aims to unravel the underlying mechanisms of mechanobiology associated inflammation and to explore the role of oxygen levels herein.
Method development for multi-modal imaging mass spectrometry (LA-ICP-MS and MALDI-MS): fusing elemental with molecular information to gain insight into hypoxia-driven processes in cancer Ghent University
Tumor hypoxia is one of the hallmarks of cancer and has turned into a central issue in cancer treatment since it is associated with malignant tumor progression, resistance to therapy and increased metastatic spread. To date, many aspects of hypoxia-induced changes in tumors remain to be elucidated. This drives the need to develop multi-modal imaging workflows for discovering and identifying key biomolecules in the heterogeneous tumor ...
Hypoxia-induced signaling and its therapeutic implications for inflammatory bowel disease and colorectal cancer Ghent University
Intestinal hypoxia occurs when local oxygen demand exceeds oxygen supply and is therefore an important hallmark of chronic inflammation such as inflammatory bowel disease (IBD), but also colorectal tumors (CRC). To counter the hypoxic challenge and ensure their survival, mucosal cells induce evolutionary conserved adaptive responses mediated by hypoxia-inducible factors (HIFs) under the control of oxygen-sensitive prolyl hydroxylases (PHD1, 2 ...