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Project
Characterisation of epigenetic control of cancer-inflammation by jumonji histone demethylases during hypoxia
Therapy resistant metastatic tumors with a bad prognosis typically demonstrate a strong inflammatory gene expression profile and severe hypoxic and hypoglycemic growth conditions.In macrophages and different tumor cell types, we want to characterize combined effects of hypoxia and inflammation on NFkB-, Stat3- and HIF-dependent signaling pathways resulting in epigenetic programming of cancer cells by PML, Jmjd3, LSD1 and SIRT chromatin-associated factors
Date:1 Jul 2010 → 31 Dec 2014
Keywords:EPIGENETICS, INFLAMMATION, HYPOXIA, CANCER RESEARCH
Disciplines:Biochemistry and metabolism, Medical biochemistry and metabolism, Morphological sciences, Oncology