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Researcher

Jorrit De Waele

  • Research interest:My research is positioned in the domain of tumor immunology and immunotherapy in solid and hematological tumors. It focusses on unraveling mechanism in the tumor microenviroment (incl. hypoxia, metabolism, checkpoints) that suppress immune cells as well as both combination and cellular therapy to overcome this suppression. In particular, I have an interest in natural killer cell, which extend to its fucntioning in patho-/physiological contexts.
  • Keywords:TUMOR MICROENVIRONMENT, IMMUNOMETABOLISM, CANCER IMMUNOTHERAPY, TUMOR OXYGENATION, IMMUNOTHERAPY, HYPOXIA, NATURAL KILLER CELLS, GLIOBLASTOMA, Medicine
  • Disciplines:Immunology, Molecular and cell biology, Oncology, Cancer therapy , Applied immunology, Immunomodulation therapy
  • Research techniques:Multicolor flow cytometrie (incl. phenotyping, cytotoxicity)Live-cell imaging (incl. behaviour and functions in mono- and cocultures)Immunoassays (incl. EISA, ICCS, multiplex electrochemiluminescence)Cell engineering (incl. CRISPR-Cas9, mRNA, electroporation, bacterial transformation)Sterile cell culture (incl. hypoxia, immune cell isolation)Mouse models (incl. orthotopic intracranial transplantation)
  • Users of research expertise:Researchers (cancer, immunotherapy, immunology)