Projects
Circulating cell-free DNA as an alternative gateway to the genetic features of multiple myeloma and as a surrogate marker for disease burden in multiple myeloma. KU Leuven
This research project explores the research hypothesis that circulating cell-free DNA(ccfDNA) can serve as a minimally-invasive substrate to remotely investigate the genome of the malignant plasma cells in multiple myeloma (MM). We will extensively validate the detection of copy number variations in ccfDNA, by paired analysis of DNA from purified plasma cells by FISH, arrayCGH and low pass sequencing by next-generation sequencing with a ...
Genetic variants associated with honey bee resistance against Deformed wing virus and their use in CRISPR-based marker assisted selection to improve resilience of bees Ghent University
Honey bees are under pressure due to abnormal high death rates, especially during the winter. The infestation by the Varroa destructor mite and the viruses that this ectoparasite transmits are generally seen as the most important biotic causes. The control of these mite-transmitted viruses is almost exclusively done in an indirect way, by limiting the severity of the mite infestation. We recently succeeded in the selection towards virus ...
Towards marker assisted selection against genetic defects in pigs. KU Leuven
Homologous Recombination Deficiency (HRD) as predictive and prognostic genetic marker in ovarian cancer - Bridging the gap between ‘one-size-fits-all’ and a more personalised treatment approach KU Leuven
Predictive markers for the use of anti-EGFR biotherapeutics in Head and Neck cancer: generation of resistant cell lines in view of microarray-based comparative genomic hybridization. University of Antwerp
Impact of air quality on health: exploiting relevant markers of exposure, effect markers and gene expression data from Flemish human biomonitoring data and other databases. Hasselt University
Valorization of a novel small scale Arabidopsis screening assay based on molecular ISR markers and identification of new biocontrol organisms (BCOs). KU Leuven
Somatic mutations and copy number alterations as prognostic markers for primary endometrial cancer KU Leuven
Systemic sclerosis and occupational silica or solvent exposure: investigating epidemiology, gene-environment interactions and objective markers of exposure to improve occupational epidemiology, risk assessment and prevention. KU Leuven
Systemic sclerosis is a rare autoimmune disease that can develop in genetically predisposed individuals upon exposure to – at present largely unknown- environmental triggers. The best available evidence supports a link between systemic sclerosis and job exposure to silica or solvents. Due to the rarity of the disease many questions remain open: what is the critical threshold of exposure above which disease will develop? Is intensity of ...