Projects
Genetic analysis, manipulation and correction of molecular pathways of blood platelet formation and function. KU Leuven
Role of CD36 in adipogenesis and adipose tissue development. KU Leuven
Reaction phenotyping and CRISPR/Cas9 genome editing of xenobiotic CYP isoenzymes in the zebrafish embryo: effects on bioactivation of prodrugs and normal functioning. University of Antwerp
Bioactivation of human proteratogens in the zebrafish embryo model, a potential alternative test for development toxicity assessment. University of Antwerp
BetaCellTherapy : Beta Cell Therapy in Diabetes. Vrije Universiteit Brussel
The γ-secretase substrate proteome and its role in cell signaling regulation KU Leuven
γ-Secretases mediate the regulated intramembrane proteolysis (RIP) of more than 150 integral membrane proteins. In some cases, a clear function can be assigned to this cleavage: for instance, it is the rate limiting step in Notch signaling. For most proteins, however, it is unclear what this cleavage exactly means. The “proteasome of the membrane” hypothesis raised by Kopan et al. in 2004, suggesting mainly a clearance function, has been ...
Identification of coding and non-coding cancer drivers from whole-genome re-sequencing data using gene regulatory network analysis. KU Leuven
Identification of coding and non-coding cancer drivers using gene regulatory network analysis
Regulation of gene transcription is an essential process, governing complex spatio-temporal expression patterns in every living cell. Gene regulation underlies processes such as the development of embryonic stem cells into various differentiated cell types, or the reprogramming of normal cells into cancer cells. Cancer is characterized by high ...
Safety first: optimizing artificial oocyte creation through diploid cell haploidization Ghent University
One out of three couples remain childless after treatments with current assisted reproductive technologies. A challenging cause is the absence of functional gametes in these couples. Therefore, the need for artificial gametes is becoming increasingly important. This proposal will tackle this need by creating de novo oocytes through diploid cell haploidization. Hereby, a diploid nucleus is injected into an enucleated oocyte. Subsequent ...
Peroxisomes and vision: what is the role of peroxisomal oxidation in the retina? KU Leuven
The crucial function of peroxisomes for vision is illustrated by the fact that prominent ophthalmological pathology, including retinopathy, occurs in nearly all peroxisomal diseases. Peroxisomes are subcellular organelles that play an essential role in oxygen and lipid metabolism, but their precise contribution to the maintenance of tissue homeostasis is still largely obscure. According to our preliminary data, the retina of mice with ...