Researcher
Steven Van Cruchten
- Research Expertise:xxxxxxx
- Keywords:TOXICOLOGY, IN VITRO TESTS, EMBRYOTOXICITY, ANIMAL MODELS, Veterinary medicine
- Disciplines:Biomarker discovery, In vitro testing, Non-clinical studies, Veterinary medicine, Other veterinary sciences
- Research techniques:-omics, ELISA, immunohistochemistry, spectrophotometry, luminiscence, LC-MS
- Users of research expertise:CROs; chemical, pharma and biotech companies
Affiliations
- Comparative Perinatal Development (CoPeD) (Research group)
Member
From1 Feb 2010 → Today
Projects
1 - 10 of 17
- Advancing the Zebrafish Embryo Developmental Toxicity Assay (ZEDTA) towards a sensitive screening assay.From1 Nov 2020 → 31 Oct 2023Funding: BOF - doctoral mandates
- Qualification of the juvenile minipig for pediatric safety testing of single stranded oligonucleotides (SSOs).From15 Jul 2020 → 14 Jul 2021Funding: BOF - doctoral mandates
- I-PREDICT: Innovative Physiology-based pharmacokinetic model to pREdict Drug exposure In neonates undergoing Cooling Therapy.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Advancing the zebrafish embryo developmental toxicity assay from screening to regulatory testing.From1 Nov 2019 → 31 Oct 2020Funding: BOF - doctoral mandates
- Assessment of skeletal endpoints and exposure in an extended Zebrafish Developmental Toxicity Assay (ZEDTA) using mammalian teratogens.From10 Apr 2018 → 9 Apr 2020Funding: Foreign public sponsor
- Bioactivation of human proteratogens in the zebrafish embryo model, a potential alternative test for development toxicity assessment.From1 Jan 2018 → 31 Dec 2021Funding: FWO Strategic Basic Research Grant
- Reaction phenotyping and CRISPR/Cas9 genome editing of xenobiotic CYP isoenzymes in the zebrafish embryo: effects on bioactivation of prodrugs and normal functioning.From1 Oct 2016 → 31 Dec 2017Funding: Fund Recuperation Fiscal Exemption
- Construction and activity of recombinant cythochrome P450 enzymes as an in vitro system for reaction-phenotyping of drug candidates in the Göttingen minipig.From18 Jul 2016 → 31 Dec 2017Funding: Foreign foundations, funds with scientific view
- Ontogeny of cytochrome P450 activity in the zebrafish: an in vitro investigation.From15 Jul 2015 → 14 Jul 2016Funding: BOF - Doctoral projects
- Development of a zebrafish embryo test for environmental risk assessment of pharmaceuticals with estrogenic properties.From1 Jan 2015 → 31 Dec 2018Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 89
- HESI workshop summary(2024)
Authors: M.L. Green, A. Kluever, Connie Chen, S. Dobreniecki, Wendy Halpern, Bethany Hannas, Alan Hoberman, M.E. Mcnerney, S. Mitchell-Ryan, T.J. Shafer, et al.
Pages: 1 - 11 - The impact of drenching on the pre-weaning resilience of low birth weight piglets(2024)
Authors: Kevin Van Tichelen, Chris Van Ginneken, Joris Michielsen, Steven Van Cruchten
Number of pages: 149 - Chronic exposure to multiple stressors alters the salivary proteome of piglets(2023)
Authors: Xaveer Van Ostade, Miriam Ayuso Hernando, Martin Dom, Geert Van Raemdonck, Steven Van Cruchten, Christophe Casteleyn, Chris Van Ginneken
Pages: 1 - 22 - Platelet activation by antisense oligonucleotides (ASOs) in the Gottingen minipig, including an evaluation of glycoprotein VI (GPVI) and platelet factor 4 (PF4) ontogeny(2023)
Authors: Allan Valenzuela, Miriam Ayuso Hernando, Laura Buyssens, Chloe Bars, Chris Van Ginneken, Yann Tessier, Steven Van Cruchten
Pages: 1 - 19 - Pharmacokinetics during therapeutic hypothermia in neonates(2023)
Authors: Karen Leys, Marina Stroe, Pieter Annaert, Steven Van Cruchten, Sebastien Carpentier, Karel Allegaert, Anne Smits
Pages: 461 - 477 - Preweaning performance in intrauterine growth-restricted piglets(2023)
Authors: Chris Van Ginneken, Miriam Ayuso Hernando, Lieselotte Van Bockstal, Steven Van Cruchten
Pages: 697 - 707 - Ontogeny of CYP3A and UGT activity in preterm piglets(2023)
Authors: Laura Buyssens, Allan Valenzuela, Miriam Ayuso Hernando, Thomas Thymann, Chris Van Ginneken, Steven Van Cruchten
Pages: 1 - 9 - The effect of drenching (very) low birth weight piglets with a dense, concentrated milk replacer at farms with differing farrowing management(2023)
Authors: Kevin Van Tichelen, Miriam Ayuso Hernando, Celine Van Kerschaver, Mario Vandaele, Jeroen Degroote, Steven Van Cruchten, Joris Michiels, Chris Van Ginneken
Pages: 1 - 18 - Development of a neonatal Gottingen Minipig model for dose precision in perinatal asphyxia(2023)
Authors: Marina Stroe, Allan Valenzuela, Miriam Ayuso Hernando, Karen Leys, Pieter Annaert, Sebastien Carpentier, Anne Smits, Karel Allegaert, Adrian Zeltner, Antonius Mulder, et al.
Pages: 1 - 19 - Ontogeny of renal, hepatic, and placental expression of ATP-binding cassette and solute carrier transporters in the rat and the rabbit(2022)
Authors: Anastasia Weyrich, Markus Frericks, Michael Eichenlaub, Steffen Schneider, Thomas Hofmann, Steven Van Cruchten, Bennard van Ravenzwaay
Pages: 1 - 9