Projects
What brain malformations can teach us: a patient-driven approach to identify molecular mechanisms involved in brain development. Vrije Universiteit Brussel
devastating but scientifically powerful diseases. At the scientific level,
the identification of novel causative genes and their corresponding
functions helps clarify the processes involved in normal brain
development. At the clinical level, patients and families can be
provided with targeted information on diagnosis and prognosis, and
can be ...
What brain malformations can teach us: a patient-driven approach to identify molecular mechanisms involved in brain development. University of Antwerp
Development of novel imaging tracers for proteolitic remodelling of the brain extracellular matrix following traumatic brain injury University of Antwerp
How does formal schooling affect the development of arithmetic, its neurocognitive predictors and its underlying brain networks? KU Leuven
At the ages 5 to 7, there are massive developmental changes in children’s neurocognitive functioning and brain development. These changes also coincide with the transition to formal education in primary school, during which there is a major change in modes of instruction from learning via less-structured playful activities in kindergarten, to learning via more structured and formal direct instruction in first grade. A critical question is how ...
Shared mechanisms causing Mowat-Wilson syndrome and Pitt-Hopkins syndrome: analysis of Sip1 and Tcf4 function in brain development, from patient to mouse to patient. KU Leuven
Data-driven microstructure imaging with multi-dimensional diffusion MRI in early brain development KU Leuven
Understanding how human brain structure develops and grows before and around the time of birth is a grand challenge in neuroscience, with far reaching implications for our understanding of neuropsychiatric disorders. Diffusion MRI (dMRI) and other quantitative MRI relaxometry modalities offer a unique means to characterize neural tissue microstructure in vivo. However, analysis of multi-dimensional dMRI in neonatal and foetal data brings ...
Functional role of Protocadherin10 in murine brain development KU Leuven
Autism Spectrum Disorders (ASDs) are a group of debilitating neurodevelopmental disorders that affect millions of patients world-wide. ASD is hypothesized to arise from a complex interplay between genetic and environmental factors that impact the structure and function of the developing brain. A potential cause of the disease pathophysiology is a disrupted excitation/inhibition balance in the central nervous system stemming from abnormal ...
Functional characterization of D630023F18Rik in the DNA damage response and brain development KU Leuven
Embryonic brains are sensitive to ionizing radiation. As a consequence, prenatal radiation exposure leads to neurological effects like microcephaly, defects in brain morphology, cognitive defects, or epilepsy. For this reason, pregnant women are so protected from ionizing radiation and get negative advice for radiotherapy. The tumor suppressor gene P53, a transcription factor, is the main regulator of the so-called DNA damage response, which ...