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Project
Development of novel imaging tracers for proteolitic remodelling of the brain extracellular matrix following traumatic brain injury
MMPs comprise a family of zinc-dependent peptidases involved in the remodelling and degradation of the ECM. MMP-9 has been identified as emerging molecular system involved in epileptogenesis. In vivo PET imaging is a powerful non-invasive tool to monitor the metabolism and properties of drugs in (pre)clinical trials. We will synthesize and evaluate the in vitro/in vivo properties of several potential MMP-9 radiotracers for brain imaging.
Date:1 Feb 2014 → 31 Dec 2014
Keywords:PET SCAN, RADIOTRACER, EPILEPSY, PROTEASE INHIBITOR
Disciplines:Organic chemistry, Medicinal products