Projects
Identification of anti-FOLR1 VHHs as novel candidates for FOLR1-targeted (brain) tumor imaging and anti-cancer therapy. Ghent University
Proliferating tissues, including several breast tumors, harbor increased folate requirement and thereby often show high folate receptor 1 (FOLR1) expression while FOLR1 expression is restricted in most healthy tissues. Breast cancer is the second most common solid malignancy that metastasizes to the brain. Reaching the brain with therapeutics appears to be extremely challenging due to the presence of brain barriers. Interestingly, the host ...
Deciphering and targeting novel immune-checkpoints engaged by dying cancer cells, to improve anti-cancer immunotherapy KU Leuven
Development of a novel class of Exportin 1 (XPO1/CRM1) inhibitors for anti-cancer therapy KU Leuven
Nuclear-cytoplasmic transport is essential for maintaining proper cellular homeostasis since it regulates the movement of large molecules (RNA and proteins) between the cytoplasm and the nucleus in a eukaryotic cells. Exportin 1 (XPO1 or CRM1) is the best characterised nuclear exporter and is responsible for the transport of a large number of different cargo proteins (e.g. p21, BCRA1, BCR-ABL and p53) to the cytoplasm. The correct ...
Intelligent polymeric nanoparticles for targeted elimination of tumor-associated macrophages as innovative anti-cancer treatment Ghent University
Besides cancer cells, tumors contain a vast array of non-cancerous cell types, which have been
largely overlooked as potential therapeutic targets and have been labeled “the forgotten half of
the tumor”. One of these non-cancerous cell types are a part of the immune system known as
macrophages. Certain macrophages undergo changes when they are present in the tumor
environment. These changes entail an overexpression of ...
OncoCiDia: an innovative, two-step anti-cancer strategy - clinical study in honder Ghent University
The abstract for "OncoCiDia" is missing. Please contact the promotor for more information.
Simplified Peloruside-analogues for anti-cancer and anti-Alzheimer therapies Ghent University
Simplified Peloruside-analogues for anti-cancer and anti-Alzheimer therapies
For reasons of confidentiality the project summary cannot be disclosed.
For more information please contact the (co)promoter.
Exploration of new microrna-based anti-cancer strategies through manipulation of endothelial cuvette metabolism KU Leuven
This project aims to achieve the first exploration of new microrna-based anti-cancer strategies through the manipulation of endothelial cuvette metabolism.
exploration of immunogenicity of apoptosis, necroptosis and autophagy in experimental anti-cancer treatments Ghent University
In this project we will explore (1) in vitro and in vivo impact of cancerous cells dying in Tet-on inducible way by apoptosis, necroptosis and autophagy on immune cells and (2) analyse the role of these cell death modalities in anti-tumor immune responses.
Exploring new microRNA-based anti-cancer strategies via manipulation of endothelial cell metabolism. KU Leuven
The aim of the project is through manipulation of endothelial cell metabolism to come to an exploration of new microRNA-based anti-cancer strategies.