Researcher
Bruno De Geest
- Keywords:immunology, polymer chemistry, Nanomedicine
- Disciplines:Biopharmaceutics, Adaptive immunology, Cancer therapy, Innate immunity, Synthesis of materials, Chemistry of clusters, colloids and nanomaterials, Macromolecular and materials chemistry not elsewhere classified, Animal immunology, Vaccines, Vaccinology
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2003 → Today
Projects
1 - 10 of 57
- A translational cancer vaccination approach based on co-delivery of tumor antigen and Toll-like receptor agonistsFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- MITACS: Multivalent Immune TArgeting synthetic Chimeric therapeuticS.From1 Jan 2023 → TodayFunding: BOF - iBOF
- A pre-targeted nanomedicine strategy for in vivo CD8+ T cell engineering.From1 Nov 2022 → TodayFunding: FWO fellowships
- Introducing mRNA vaccination in chicken: first steps towards a commercial mRNA vaccine against a leading viral infection in chickenFrom1 Nov 2022 → TodayFunding: IOF - technology validation in lab
- A novel CRISPR/Cas9-based nanomedicine strategy targeting CD4+ cells to cure HIVFrom1 Nov 2022 → TodayFunding: FWO fellowships
- Non-covalent hapten-immunogen next generation anti-opioid nanovaccinesFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- A novel CRISPR/Cas9-based nanomedicine strategy targeting CD4+ cells to cure HIVFrom1 Oct 2022 → 31 Oct 2022Funding: BOF - doctoral mandates
- MATRACs / Membrane Anchoring Trafficking ChimerasFrom1 Oct 2022 → TodayFunding: BOF - doctoral mandates
- Normalising tumour pH to bring the STING back in anti-tumour immunityFrom1 Oct 2021 → TodayFunding: FWO junior postdoctoral fellowship
- A targeted nanomedicine strategy for in vivo CD8+ T cell engineeringFrom1 Oct 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
Publications
1 - 10 of 207
- An intelligent nanovehicle armed with multifunctional navigation for precise delivery of tollU+2010like receptor 7/8 agonist and immunogenic cell death amplifiers to eliminate solid tumors and trigger durable antitumor immunity(2022)
Authors: Yanyun Hao, Hui Li, Huajun Zhao, Yutong Liu, Xiaoyan Ge, Xia Li, Hongfei Chen, Ailu Yang, Jing Zou, Xue Li, et al.
- pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages(2022)
Authors: Leonard Kaps, Anne Huppertsberg, Niklas Choteschovsky, Adrian Klefenz, Feyza Durak, Babara Schrörs, Mustafa Diken, Emma Eichler, Sebastian Rosigkeit, Sascha Schmitt, et al.
- In situ tumor vaccination with calcium‐linked degradable coacervate nanocomplex co‐delivering photosensitizer and TLR7/8 agonist to trigger effective anti‐tumor immune responses(2022)
Authors: Yutong Liu, Hui Li, Huajun Zhao, Yanyun Hao, Simon Van Herck, Zejun Xu, Guan Wang, Xiao Wang, Xinke Zhang, Xiaoyan Ge, et al.
- Lipid nature and alkyl length influence lymph node accumulation of lipid-polyethylene glycol amphiphiles(2021)
Authors: Jana De Vrieze, Antonio Pires da Silva Baptista, Lutz Nuhn, Simon Van Herck, Kim Deswarte, Haijun Yu, Bart Lambrecht, Bruno De Geest
- Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-)analytical variables(2021)
Authors: Edward Geeurickx, Lien Lippens, Pekka Rappu, Bruno De Geest, Olivier De Wever, An Hendrix
Pages: 603 - 633 - Sterilizing immunity against SARSU+2010CoVU+20102 infection in mice by a singleU+2010shot and lipid amphiphile imidazoquinoline TLR7/8 agonistU+2010adjuvanted recombinant spike protein vaccine**(2021)
Authors: Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Simon Van Herck, Lutz Nuhn, Kim Deswarte, Zifu Zhong, et al.
Pages: 9467 - 9473 - Biomaterials applications of cyclic polymers(2021)
Authors: Bianka Golba, Edmondo M. Benetti, Bruno De Geest
- Delivery routes matter : safety and efficacy of intratumoral immunotherapy(2021)
Authors: Emily De Lombaerde, Olivier De Wever, Bruno De Geest
- Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators(2021)
Authors: Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Kim Deswarte, Francis Combes, Christian Czysch, Jana De Vrieze, Sabah Kasmi, et al.
Pages: 9872 - 9883 - Covalent cell surface conjugation of nanoparticles by a combination of metabolic labeling and click chemistry(2021)
Authors: Alexander Lamoot, Annemiek Uvyn, Sabah Kasmi, Bruno De Geest
Pages: 6320 - 6325