Researcher
Peter de Witte
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Molecular Biodiscovery (Division)
Responsible
From1 Apr 2013 → Today - Molecular Biodiscovery (Division)
Member
From1 Apr 2013 → Today
Projects
1 - 10 of 31
- PHGDH-ASM: Phosphoglycerate dehydrogenase (PHGDH) activators as novel antiseizure medications (ASM) with dual mode of actionFrom1 Oct 2022 → TodayFunding: IOF - technology validation in lab
- Excitation-inhibition imbalance in autism-epilepsy comorbidity, a preclinical and clinical studyFrom1 Oct 2021 → 30 Sep 2023Funding: BOF - projects
- Development of innovative multi-dimensional liquid chromatography methods for the analysis of organic micropollutants and their degradation products in environmental waterFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Therapeutic strategies for Dravet syndrome: upregulation of endogenous SCN1A and modulation of remodelingFrom1 Jun 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Multi-dimensional liquid chromatography for the analysis of complex samples.From1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- SmartDetox - Removal of organic micropollutants from waterFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Unraveling the in vivo host cell tropism and virus dissemination strategies of human norovirus.From28 Sep 2020 → TodayFunding: FWO fellowships
- A Lattice Light Sheet microscope to image subcellular molecular dynamics, cellular forces, neuroimmune interactions and neuronal activity in 3DFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Toxicity assessment of degradation products using zebrafish and advanced LC-MS techniquesFrom6 Jan 2020 → 6 Jan 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- An antisense strategy and network pharmacology approach in zebrafish models to identify novel targets for pharmacoresistant epilepsyFrom1 Nov 2019 → 30 Sep 2023Funding: FWO Strategic Basic Research Grant
Publications
41 - 50 of 146
- Cannabidiol modulates phosphorylated rpS6 signalling in a zebrafish model of Tuberous Sclerosis Complex(2019)
Authors: Chloë Scheldeman, Peter de Witte
Pages: 135 - 144 - Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos(2019)
Authors: Arianna Giusti, Mélanie Mignot, Pieter Annaert, Annelii Ny, Deirdre Cabooter, Peter de Witte
- Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy(2019)
Authors: Camila Esguerra, Fred Van Leuven, Peter de Witte
Pages: 1992 - 2003 - Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model(2019)
Authors: Maoxuan Liu, Daniëlle Copmans, Jo Sourbron, Annelii Ny, Peter de Witte, Walter Luyten
Pages: 130 - 134 - Modeling epileptic seizures in zebrafish using genetic and chemical tools(2019)
Authors: Yifan Zhang, Peter de Witte
- Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish(2019)
Authors: Aleksandra Siekierska, Michèle Partoens, Jo Sourbron, Peter de Witte
- Drug repurposing for Dravet syndrome in scn1Lab-/- mutant zebrafish(2019)
Authors: Jo Sourbron, Michèle Partoens, Chloë Scheldeman, Lieven Lagae, Peter de Witte
Pages: E8 - E13 - Detection of Drug-Induced Cholestasis Potential in Sandwich-Cultured Human Hepatocytes(2019)
Authors: Neel Deferm, Pieter Van Brantegem, Tom De Vocht, Bing Qi, Peter de Witte, Thomas Bouillon, Pieter Annaert
Pages: 335 - 350Number of pages: 16 - Genetic Renal Diseases: The Emerging Role of Zebrafish Models(2018)
Authors: Sante Princiero Berlingerio, Bert van den Heuvel, Peter de Witte, Elena Levtchenko
- Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A(2018)
Authors: Daniëlle Copmans, Peter de Witte
Pages: 1652 - 1662
Patents
1 - 10 of 10
- Treatment of pharmacoresistant epilepsy (Inventor)
- Idebenone in the treatment of drug resistant epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Anticonvulsant activity of bisabolene sesquiterpenoids isolated from turmeric oil (Inventor)
- Anticonvulsant activity of turmeric oil and bisabolene sesquiterpenoids (Inventor)