Researcher
Peter de Witte
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Molecular Biodiscovery (Division)
Responsible
From1 Apr 2013 → Today - Molecular Biodiscovery (Division)
Member
From1 Apr 2013 → Today
Projects
1 - 10 of 31
- PHGDH-ASM: Phosphoglycerate dehydrogenase (PHGDH) activators as novel antiseizure medications (ASM) with dual mode of actionFrom1 Oct 2022 → TodayFunding: IOF - technology validation in lab
- Excitation-inhibition imbalance in autism-epilepsy comorbidity, a preclinical and clinical studyFrom1 Oct 2021 → 30 Sep 2023Funding: BOF - projects
- Development of innovative multi-dimensional liquid chromatography methods for the analysis of organic micropollutants and their degradation products in environmental waterFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Therapeutic strategies for Dravet syndrome: upregulation of endogenous SCN1A and modulation of remodelingFrom1 Jun 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Multi-dimensional liquid chromatography for the analysis of complex samples.From1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- SmartDetox - Removal of organic micropollutants from waterFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Unraveling the in vivo host cell tropism and virus dissemination strategies of human norovirus.From28 Sep 2020 → TodayFunding: FWO fellowships
- A Lattice Light Sheet microscope to image subcellular molecular dynamics, cellular forces, neuroimmune interactions and neuronal activity in 3DFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Toxicity assessment of degradation products using zebrafish and advanced LC-MS techniquesFrom6 Jan 2020 → 6 Jan 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- An antisense strategy and network pharmacology approach in zebrafish models to identify novel targets for pharmacoresistant epilepsyFrom1 Nov 2019 → 30 Sep 2023Funding: FWO Strategic Basic Research Grant
Publications
11 - 20 of 146
- Antiseizure activity by opioid receptor antagonism, new evidence(2022)
Authors: Peter de Witte
Pages: 229 - 230 - Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery(2022)
Authors: Lise Heylen, Michèle Partoens, Peter de Witte, Aleksandra Siekierska
- From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin.(2022)
Authors: Daniëlle Copmans, Emma Roux, Michèle Partoens, Gert Steurs, Wim De Borggraeve, Peter de Witte
- Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation(2022)
Authors: Aleksandra Siekierska, Peter de Witte
- Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting(2022)
Authors: Nicole Rufo, Rita Derua, Abhishek Garg, Michael Dewaele, Peter de Witte, Steven Verhelst, Patrizia Agostinis
Pages: 230 - 245 - Use of fluorescent probes to study pharmacokinetics in zebrafish (Danio rerio) embryos and larvae(2021)
Authors: Marlly Guarin, Peter de Witte, Pieter Annaert, Annelii Ny
- Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish(2021)
Authors: Peter de Witte, Daniëlle Copmans
- Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish(2021)
Authors: Lise Heylen, Ann-Sofie De Meulemeester, Daniëlle Copmans, Youcef Kazwiny, Pieter Vanden Berghe, Peter de Witte, Aleksandra Siekierska
- A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo(2021)
Authors: Jana Van Dycke, Arno Cuvry, Emma Roux, Peter de Witte, Johan Neyts, Joana Duarte Da Rocha Pereira
- Pre-validation of choriogenin H transgenic medaka eleutheroembryos as a quantitative estrogenic activity test method(2021)
Authors: Peter de Witte, Annelii Ny
Patents
1 - 10 of 10
- Treatment of pharmacoresistant epilepsy (Inventor)
- Idebenone in the treatment of drug resistant epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Anticonvulsant activity of bisabolene sesquiterpenoids isolated from turmeric oil (Inventor)
- Anticonvulsant activity of turmeric oil and bisabolene sesquiterpenoids (Inventor)