Researcher
Peter de Witte
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Molecular Biodiscovery (Division)
Responsible
From1 Apr 2013 → Today - Molecular Biodiscovery (Division)
Member
From1 Apr 2013 → Today
Projects
1 - 10 of 31
- PHGDH-ASM: Phosphoglycerate dehydrogenase (PHGDH) activators as novel antiseizure medications (ASM) with dual mode of actionFrom1 Oct 2022 → TodayFunding: IOF - technology validation in lab
- Excitation-inhibition imbalance in autism-epilepsy comorbidity, a preclinical and clinical studyFrom1 Oct 2021 → 30 Sep 2023Funding: BOF - projects
- Development of innovative multi-dimensional liquid chromatography methods for the analysis of organic micropollutants and their degradation products in environmental waterFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Therapeutic strategies for Dravet syndrome: upregulation of endogenous SCN1A and modulation of remodelingFrom1 Jun 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Multi-dimensional liquid chromatography for the analysis of complex samples.From1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- SmartDetox - Removal of organic micropollutants from waterFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Unraveling the in vivo host cell tropism and virus dissemination strategies of human norovirus.From28 Sep 2020 → TodayFunding: FWO fellowships
- A Lattice Light Sheet microscope to image subcellular molecular dynamics, cellular forces, neuroimmune interactions and neuronal activity in 3DFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Toxicity assessment of degradation products using zebrafish and advanced LC-MS techniquesFrom6 Jan 2020 → 6 Jan 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- An antisense strategy and network pharmacology approach in zebrafish models to identify novel targets for pharmacoresistant epilepsyFrom1 Nov 2019 → 30 Sep 2023Funding: FWO Strategic Basic Research Grant
Publications
31 - 40 of 146
- Towards the development of norovirus antiviral drugs: zebrafish larvae as an innovative model system to study the replication of human norovirus(2020)
Authors: Jana Van Dycke, Johan Neyts, Peter de Witte, Joana Duarte Da Rocha Pereira
- Modeling Renal Fibrosis in Zebrafish Using Aristolochic Acid I(2020)
Authors: Xixin Wang, Peter de Witte
- Drug-induced cholestasis: in vitro detection and mechanistic insights(2020)
Authors: Neel Deferm, Pieter Annaert, Peter de Witte
- Fenfluramine acts as a positive modulator of sigma-1 receptors(2020)
Authors: Peter de Witte
- Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid(2020)
Authors: Xixin Wang, Arianna Giusti, Annelii Ny, Peter de Witte
- Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model(2020)
Authors: jing Li, Daniëlle Copmans, Michèle Partoens, Walter Luyten, Peter de Witte
Pages: 730 - 742 - Onchocerca volvulus is not detected in the cerebrospinal fluid of persons with onchocerciasis-associated epilepsy(2020)
Authors: Peter de Witte
Pages: 119 - 123 - Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B(2019)
Authors: Daniëlle Copmans, Michèle Partoens, Camila Esguerra, Peter de Witte
- A robust human norovirus replication model in zebrafish larvae(2019)
Authors: Jana Van Dycke, Annelii Ny, Arno Cuvry, Erik Verbeken, Jelle Matthijnssens, Peter de Witte, Johan Neyts, Joana Duarte Da Rocha Pereira
- Current insights in the complexities underlying drug-induced cholestasis(2019)
Authors: Neel Deferm, Tom De Vocht, Bing Qi, Pieter Van Brantegem, Peter de Witte, Thomas Bouillon, Pieter Annaert
Pages: 520 - 548
Patents
1 - 10 of 10
- Treatment of pharmacoresistant epilepsy (Inventor)
- Idebenone in the treatment of drug resistant epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Anticonvulsant activity of bisabolene sesquiterpenoids isolated from turmeric oil (Inventor)
- Anticonvulsant activity of turmeric oil and bisabolene sesquiterpenoids (Inventor)