Researcher
Peter de Witte
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Molecular Biodiscovery (Division)
Responsible
From1 Apr 2013 → Today - Molecular Biodiscovery (Division)
Member
From1 Apr 2013 → Today
Projects
1 - 10 of 31
- PHGDH-ASM: Phosphoglycerate dehydrogenase (PHGDH) activators as novel antiseizure medications (ASM) with dual mode of actionFrom1 Oct 2022 → TodayFunding: IOF - technology validation in lab
- Excitation-inhibition imbalance in autism-epilepsy comorbidity, a preclinical and clinical studyFrom1 Oct 2021 → 30 Sep 2023Funding: BOF - projects
- Development of innovative multi-dimensional liquid chromatography methods for the analysis of organic micropollutants and their degradation products in environmental waterFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Therapeutic strategies for Dravet syndrome: upregulation of endogenous SCN1A and modulation of remodelingFrom1 Jun 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Multi-dimensional liquid chromatography for the analysis of complex samples.From1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- SmartDetox - Removal of organic micropollutants from waterFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Unraveling the in vivo host cell tropism and virus dissemination strategies of human norovirus.From28 Sep 2020 → TodayFunding: FWO fellowships
- A Lattice Light Sheet microscope to image subcellular molecular dynamics, cellular forces, neuroimmune interactions and neuronal activity in 3DFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Toxicity assessment of degradation products using zebrafish and advanced LC-MS techniquesFrom6 Jan 2020 → 6 Jan 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- An antisense strategy and network pharmacology approach in zebrafish models to identify novel targets for pharmacoresistant epilepsyFrom1 Nov 2019 → 30 Sep 2023Funding: FWO Strategic Basic Research Grant
Publications
21 - 30 of 146
- Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of kif2a in Zebrafish(2021)
Authors: Michèle Partoens, Ann-Sofie De Meulemeester, Peter de Witte, Aleksandra Siekierska
- Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome(2021)
Authors: Maxim Nelis, Jo Sourbron, Daniëlle Copmans, Lieven Lagae, Deirdre Cabooter, Peter de Witte
Pages: 2249 - 2261 - Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis(2021)
Authors: Sante Princiero Berlingerio, Lies De Groef, Harold Taeter, Tomas Norton, Peter de Witte, Bert van den Heuvel, Elena Levtchenko
- An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies(2021)
Authors: Jo Sourbron, Peter de Witte
- Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration(2021)
Authors: Marlly Guarin, Ruben Faelens, Deirdre Cabooter, Pieter Annaert, Peter de Witte, Annelii Ny
- Using Zebrafish as a Disease Model to Study Fibrotic Disease(2021)
Authors: Daniëlle Copmans, Peter de Witte
- Using Zebrafish as a Disease Model to Study Fibrotic Disease(2021)
Authors: Xixin Wang, Daniëlle Copmans, Peter de Witte
- Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors(2021)
Authors: Jana Van Dycke, Arno Cuvry, Annelii Ny, Peter de Witte, Johan Neyts, Joana Duarte Da Rocha Pereira
Pages: 1830 - + - G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling(2021)
Authors: Ann-Sofie De Meulemeester, Aleksandra Siekierska, Peter de Witte
Pages: 655 - + - Discovery of Antiseizure Compounds in Zebrafish Models for the Treatment of Drug-Resistant Epilepsy(2020)
Authors: jing Li, Peter de Witte, Walter Luyten
Patents
1 - 10 of 10
- Treatment of pharmacoresistant epilepsy (Inventor)
- Idebenone in the treatment of drug resistant epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Anticonvulsant activity of bisabolene sesquiterpenoids isolated from turmeric oil (Inventor)
- Anticonvulsant activity of turmeric oil and bisabolene sesquiterpenoids (Inventor)