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Researcher
Karen Vanhoorelbeke
- Disciplines:Biochemistry and metabolism, Cardiac and vascular medicine, Medical biochemistry and metabolism
Affiliations
- Chemistry, Kulak Kortrijk Campus (Department)
Responsible
From1 Oct 2018 → Today - Chemistry, Kulak Kortrijk Campus (Department)
Member
From1 Jan 2009 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2004 → 30 Sep 2006 - Faculty of Science, Kulak Kortrijk Campus (Faculty)
Member
From1 Oct 2000 → 31 Dec 2008
Projects
1 - 10 of 58
- B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVDFrom1 Oct 2023 → TodayFunding: Horizon Europe - European Innovation Council (EIC)
- A novel targeted therapy to treat bleeding in patients with a left ventricular assist device.From1 May 2023 → TodayFunding: IOF - mandates
- Universal Chimeric Antigen Receptor (UniCAR) T-cell therapy: an innovative treatment for autoimmune diseaseFrom5 Apr 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Universal chimeric antigen receptor (uniCAR)-T cell therapy to treat autoimmune diseases: immune mediated thrombotic thrombocytopenic purpura as a model system.From1 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Flow cytometer for the Interdisciplinary Research Facility Life Sciences at Campus Kulak KortrijkFrom1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Allosteric ADAMTS13 activation: elucidating long-range structural crosstalk bringing the enzyme in a preactivated stateFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- An integrated approach to restore tolerance in autoimmune diseaseFrom1 Oct 2022 → TodayFunding: HORIZON.1.2 - Marie Skłodowska-Curie-actions (MSCA)
- Next-generation DNA vectors to improve efficacy, precision and accessibility of antibody gene transferFrom15 Mar 2022 → 14 Mar 2024Funding: BOF - various
- Innovative approaches to tackle autoimmune diseases: immune-mediated thrombotic thrombocytopenic purpura as a disease modelFrom1 Jul 2021 → 30 Jun 2023Funding: BOF - various
- A novel biomarker to improve the quality of life of immune mediatied thrombotic thrombocytopenic purpura patients.From1 Jun 2021 → 31 May 2023Funding: Foreign foundations, funds with scientific view
Publications
21 - 30 of 210
- The GPIbα intracellular tail - role in transducing VWF- and collagen/GPVI-mediated signaling(2022)
Authors: Karen Vanhoorelbeke
Pages: 933 - 946 - Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear(2022)
Authors: Karen Vanhoorelbeke
- Staphylococcus aureus iron-regulated surface determinant B (IsdB) protein interacts with von Willebrand factor and promotes adherence to endothelial cells(2021)
Authors: Karen Vanhoorelbeke
- Gold nanoparticle enhanced multiplexed biosensing on a fiber optic surface plasmon resonance probe(2021)
Authors: Karen Vanhoorelbeke, Jeroen Lammertyn, Dragana Spasic
- Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP(2021)
Authors: Laure De Waele, Claudia Tersteeg, Simon De Meyer, Karen Vanhoorelbeke
Pages: 4480 - 4484 - Miniaturized single-cell technologies for monoclonal antibody discovery(2021)
Authors: Julie Van Lent, Jolien Breukers, Karen Ven, Louanne Ampofo, Maya Imbrechts, Nick Geukens, Karen Vanhoorelbeke, Paul Declerck, Jeroen Lammertyn
Pages: 3627 - 3654 - Conformational plasticity of ADAMTS13 in hemostasis and autoimmunity(2021)
Authors: Karen Vanhoorelbeke
- Plasma and rhADAMTS13 reduce trauma-induced organ failure by restoring the ADAMTS13-VWF axis(2021)
Authors: Charlotte Dekimpe, Shannen Deconinck, Karen Vanhoorelbeke
Pages: 3478 - 3491 - Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura(2021)
Authors: Simon De Meyer, Karen Vanhoorelbeke
Pages: 3427 - 3435 - Determination of anti-ADAMTS-13 autoantibody titers in ELISA: Influence of ADAMTS-13 presentation and autoantibody detection(2021)
Authors: Charlotte Dekimpe, Kadri Kangro, Quintijn Bonnez, Claudia Tersteeg, Simon De Meyer, Karen Vanhoorelbeke
Pages: 2248 - 2255
Patents
1 - 9 of 9
- Haemorrhagic disorder due to ventricular assist device (Inventor)
- Humanised adamts13 binding antibodies (Inventor)
- Screening and sorting of single cells (Inventor)
- Anti adamts13 antibodies and their use for treatment or prevention of haemorrhagic disorders due to ventricular assist device (Inventor)
- Humanised adamts13 binding antibodies (Inventor)
- Screening and sorting of single cells (Inventor)
- Haemorrhagic disorder due to ventricular assist device (Inventor)
- Humanised adamts13 binding antibodies (Inventor)
- Anti adamts13 antibodies and their use for treatment or prevention of haemorrhagic disorders due to ventricular assist device (Inventor)