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Researcher
Karen Vanhoorelbeke
- Disciplines:Biochemistry and metabolism, Cardiac and vascular medicine, Medical biochemistry and metabolism
Affiliations
- Chemistry, Kulak Kortrijk Campus (Department)
Responsible
From1 Oct 2018 → Today - Chemistry, Kulak Kortrijk Campus (Department)
Member
From1 Jan 2009 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2004 → 30 Sep 2006 - Faculty of Science, Kulak Kortrijk Campus (Faculty)
Member
From1 Oct 2000 → 31 Dec 2008
Projects
21 - 30 of 58
- Rapid and easy-to-perform FO-SPR-based assays for VWF antigen and functionality and insights into the vaccine-induced adaptive immune response against SARS-CoV-2From1 Aug 2019 → 25 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Neutrophil Extracellular Traps, von Willebrand factor and Extracellular DNA as mediators of Ischemic Stroke PathogenesisFrom1 Apr 2019 → 12 May 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Tau oligomers as target for novel Alzheimer’s disease diagnostics and therapeuticsFrom8 Nov 2018 → 6 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Towards a rapid diagnostic test for thrombotic thrombocytopenic purpuraFrom30 Oct 2018 → 31 Oct 2021Funding: FWO Strategic Basic Research Grant
- Towards a rapid diagnostic test for thrombotic thrombocytopenic purpuraFrom1 Oct 2018 → 30 Sep 2022Funding: FWO Applied Biomedical Research (TBM)
- Autoantibodies in autoimmune-mediated thrombotic thrombocytopenic purpura: from mechanistic insights towards the first steps in targeted therapyFrom1 Oct 2018 → 30 Sep 2020Funding: BOF - Bilateral scientific cooperation
- Bleeding after left ventricular assist device implantation in heart patients: a novel therapyFrom1 Oct 2017 → 30 Sep 2019Funding: IOF - Industrial Research Fund
- Mouse housing and micorscopy platform for cardiovascular and antibody-based researchFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Gene therapy for thrombotic thrombocytopenic purpura (TTP)From1 Sep 2016 → 28 Oct 2021Funding: FWO fellowships
- Integrated Diagnostic and Life Science Research Tools (IDiaLiST)From1 Sep 2016 → 31 Dec 2023Funding: IOF - mandates, IOF - Industrial Research Fund
Publications
1 - 10 of 209
- Open ADAMTS-13 conformation index predicts earlier relapse in immune-mediated thrombotic thrombocytopenic purpura(2024)
Authors: Claudia Tersteeg, Karen Vanhoorelbeke
Pages: 493 - 502 - Management and follow-up of pregnancy-onset thrombotic thrombocytopenic purpura: the French experience(2024)
Authors: Karen Vanhoorelbeke
Pages: 183 - 193 - Hemophagocytic lymphohistiocytosis is associated with deficiency and closed conformation of ADAMTS-13(2024)
Authors: Karen Vanhoorelbeke
- Impact of N-glycan mediated shielding of ADAMTS-13 on the binding of pathogenic antibodies in immune thrombotic thrombocytopenic purpura(2023)
Authors: Karen Vanhoorelbeke
Pages: 3402 - 3413 - FLUIDOT: A case study on drug tolerance screening and antibody mining, one cell at a time(2023)
Authors: Karen Ven, Jolien Breukers, Iene Rutten, Maya Imbrechts, Sam Noppen, Dominique Schols, Paul De Munter, Hendrik Jan Thibaut, Karen Vanhoorelbeke, Dragana Spasic, et al.
- ADAMTS13 and Non-ADAMTS13 Biomarkers in Immune-Mediated Thrombotic Thrombocytopenic Purpura(2023)
Authors: Quintijn Bonnez, Karen Vanhoorelbeke
- Measuring ADAMTS-13 activity to diagnose thrombotic thrombocytopenic purpura: a novel, fast fiber-optic surface plasmon resonance immunoassay(2023)
Authors: Quintijn Bonnez, Peter Verhamme, Claudia Tersteeg, Simon De Meyer, Jeroen Lammertyn, Karen Vanhoorelbeke
- Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity(2023)
Authors: Simon De Meyer, Karen Vanhoorelbeke, Claudia Tersteeg
- Comparison of ADAMTS13 activity testing platforms for diagnosis and monitoring of thrombotic thrombocytopenic purpura(2023)
Authors: Karen Vanhoorelbeke
Pages: 26 - 26 - In vitro characterization of a novel Arg102 mutation in the ADAMTS13 metalloprotease domain(2023)
Authors: Claudia Tersteeg, Simon De Meyer, Karen Vanhoorelbeke
Pages: 682 - 690
Patents
1 - 9 of 9
- Haemorrhagic disorder due to ventricular assist device (Inventor)
- Humanised adamts13 binding antibodies (Inventor)
- Screening and sorting of single cells (Inventor)
- Anti adamts13 antibodies and their use for treatment or prevention of haemorrhagic disorders due to ventricular assist device (Inventor)
- Humanised adamts13 binding antibodies (Inventor)
- Screening and sorting of single cells (Inventor)
- Haemorrhagic disorder due to ventricular assist device (Inventor)
- Humanised adamts13 binding antibodies (Inventor)
- Anti adamts13 antibodies and their use for treatment or prevention of haemorrhagic disorders due to ventricular assist device (Inventor)