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Researcher
Joris de Wit
- Disciplines (Flanders Institute for Biotechnology):Bioinformatics and computational biology, Molecular and cell biology, Neurosciences
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Affiliations
- Laboratory of Synapse Biology (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2013 → Today - Laboratory of Synapse Biology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - VIB-KU Leuven Center for Brain & Disease Research (Research Center)
Responsible
From1 Jan 2017 → Today - de Wit Lab (Research group)
Responsible
From1 Jan 2017 → 31 Dec 2020 - Department of Human Genetics (Department)
Member
From1 Jan 2013 → 31 Dec 2016
Projects
1 - 10 of 30
- Microglia-synapse molecular interactions in Alzheimer's diseaseFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unravelling the regulatory code orchestrating neural circuit formationFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2021 → TodayFunding: BOF - Methusalem
- Development and Specification of Cortical Layer 1 MicrocircuitsFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Role of cell-surface receptor signaling mechanisms in dendritic spine maturation and plasticityFrom26 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synapse type-specific multi-omics mapping of sensory experience-induced plasticityFrom1 Nov 2020 → TodayFunding: FWO junior postdoctoral fellowship
- Mapping of input-specific protein repertoires using state-of-the art genome engineering and imaging tools.From1 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping the synaptic proteome through site-specific protein biotinylationFrom1 Oct 2020 → TodayFunding: FWO senior postdoctoral fellowship
- Mapping the cell-surface molecule repertoires patterning hippocampal CA1 border interneuron connectivityFrom15 Sep 2020 → TodayFunding: FWO fellowships
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 37
- KIF2A deficiency causes early-onset neurodegeneration.(2022)
Authors: Joris de Wit
Pages: e220971411 - Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function(2021)
Authors: Joris de Wit
- Role of regulatory C-terminal motifs in synaptic confinement of LRRTM2(2021)
Authors: Joris de Wit
Pages: 492 - 506 - Mapping the cell-surface proteome underlying synapse type-specific identity(2020)
Authors: Nuno Apóstolo, Joris de Wit
- Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer(2020)
Authors: Natalia Gunko, Joris de Wit
- Contribution of GABAergic interneurons to amyloid-beta plaque pathology in an APP knock-in mouse model(2020)
Authors: Gabriele Marcassa, Iordana Chrysidou, Joris de Wit, Bart De Strooper
- SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function(2019)
Authors: Luís Filipe da Silva Ribeiro, Ben Verpoort, Joris de Wit
- Compartmentalized distributions of neuronal and glial cell-surface proteins pattern the synaptic network(2019)
Authors: Joris de Wit
Pages: 126 - 133 - Nuclear import of the dscam-cytoplasmic domain drives signaling capable of inhibiting synapse formation(2019)
Authors: Sonja Sachse, Luís Filipe da Silva Ribeiro, Dan Dascenco, Evgenia Salta, Wouter Van Delm, Stéphane Plaisance, Bart De Strooper, Joris de Wit, Dietmar Schmucker
Pages: 1 - 19 - Glypicans as novel regulators of synaptic connectivity(2019)
Authors: Giuseppe Condomitti, Joris de Wit
Patents
1 - 3 of 3