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Organisation
Laboratory of Synapse Biology (VIB-KU Leuven)
Lab
Main organisation:Research Group Molecular Neurobiology (VIB-KU Leuven)
Lifecycle:1 Jan 2013 → Today
Organisation profile:
The Laboratory of Synapse Biology aims to unravel the molecular mechanisms that control neuronal connectivity in developing circuits, and determine how perturbations in this process affect cognitive function.
Keywords:Synapse
Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Current researchers
1 - 10 of 15 results
- Joris de Wit (Responsible)
- Lucas Baltussen (Member)
- Stephanie Chanda (Member)
- Danie Daaboul (Member)
- Dan Dascenco (Member)
- Cydric Geyskens (Member)
- Efstathia Artemis Koumoundourou (Member)
- Elke Leysen (Member)
- Blanca Lorente Echeverría (Member)
- Gabriele Marcassa (Member)
Projects
1 - 10 of 34
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Microglia-synapse molecular interactions in Alzheimer's diseaseFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unravelling the regulatory code orchestrating neural circuit formationFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2021 → TodayFunding: BOF - Methusalem
- Development and Specification of Cortical Layer 1 MicrocircuitsFrom1 Sep 2021 → 22 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of cell-surface receptor signaling mechanisms in dendritic spine maturation and plasticityFrom26 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synapse type-specific multi-omics mapping of sensory experience-induced plasticityFrom1 Nov 2020 → 31 Dec 2022Funding: FWO junior postdoctoral fellowship
- Mapping of input-specific protein repertoires using state-of-the art genome engineering and imaging tools.From1 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping the synaptic proteome through site-specific protein biotinylationFrom1 Oct 2020 → 30 Sep 2023Funding: FWO senior postdoctoral fellowship
- Mapping the cell-surface molecule repertoires patterning hippocampal CA1 border interneuron connectivityFrom15 Sep 2020 → TodayFunding: FWO fellowships
Publications
1 - 10 of 71
- Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons.
Authors: Teun Maria Klein Gunnewiek
Pages: 105587 - Retinal lesions induce fast intrinsic cortical plasticity in adult mouse visual system(2016)
Authors: Katrien Smolders, Samme Vreysen, Marie-Eve Laramée, Tjing Hu, Julie Nys, Lut Arckens
Pages: 2165 - 2175 - Compartmentalized distributions of neuronal and glial cell-surface proteins pattern the synaptic network(2019)
Authors: Joris de Wit
Pages: 126 - 133 - Synapse biology in the 'circuit-age'-paths toward molecular connectomics(2017)
Authors: Joris de Wit
Pages: 102 - 110 - Leucine-rich repeat-containing synaptic adhesion molecules as organizers of synaptic specificity and diversity(2018)
Authors: Anna Schroeder, Joris de Wit
- Specification of synaptic connectivity by cell surface interactions(2016)
Authors: Joris de Wit, Anirvan Ghosh
Pages: 22 - 35 - Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease(2023)
Authors: Nicky Thrupp, Mark Fiers, Joris de Wit, Kristofer Davie, Dietmar Thal, Bart De Strooper
Pages: 1021 - + - The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning(2017)
Authors: Emanuela Pasciuto, Tiziana Girardi, Julie Nys, Lut Arckens, Claudia Bagni
- Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation(2021)
Authors: Luís Filipe da Silva Ribeiro
- Extracellular Sphingosine-1-Phosphate: A Novel Actor in Human Glioblastoma Stem Cell Survival
Authors: Giuseppe Condomitti