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Researcher
Joris de Wit
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Cell signalling, Intracellular compartments and transport, Membrane structure and transport, Cognitive neuroscience, Developmental neuroscience, Neurological and neuromuscular diseases
- See also: De Wit Joris (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Synapse Biology (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2013 → Today - Laboratory of Synapse Biology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - de Wit Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Jan 2013 → 31 Dec 2016
Projects
21 - 30 of 31
- Synaptrode: neural interfacing at the synapse levelFrom1 Sep 2017 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
- Key Determinants of Synaptic Excitation/Inhibition Imbalance in Autism Spectrum Disorders - From Genetic Animal Models to Human PatientsFrom1 Jul 2016 → 30 Jun 2021Funding: FWO research project (including WEAVE projects)
- Synaptic adhesion molecule sorting and the control of excitation/inhibition balance in the brainFrom1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits.From1 Oct 2015 → 31 Aug 2021Funding: FWO fellowships
- Analysing the function of APP as Wnt signaling receptor and the relevance for the Alzheimer disease.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Mapping the cell-surface proteome underlying synapse type-specific identityFrom13 Oct 2014 → 15 Oct 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Translating genetics of neurodegenerative disorders into therapeutic strategies.From1 Oct 2014 → 30 Sep 2021Funding: BOF - Methusalem
- Breaking down the molecular code directing specific synaptic connectivity in hippocampal circuits.From1 Oct 2014 → 1 Jun 2016Funding: FWO fellowships
- “Building a synapse: Investigation of the role of LRRTM1 and FLRT2 in synapse development in vivo”From2 Sep 2013 → 26 Nov 2018Funding: FWO fellowships
- Glypicans as novel regulators of synaptic connectivityFrom22 Apr 2013 → 28 Jan 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 46
- The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation.(2024)
Authors: Lucas Baltussen, Joris de Wit
Pages: eadf7001 - Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold.(2024)
Authors: Ben Verpoort, Joris de Wit
Pages: a041501 - LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons(2023)
Authors: Sofie Beckers, Katerina Konstantoulea, Maarten Dewilde, Frederic Rousseau, Joost Schymkowitz, Tom Theys, Joris de Wit, Pierre Vanderhaeghen
- Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease(2023)
Authors: Nicky Thrupp, Mark Fiers, Joris de Wit, Kristofer Davie, Dietmar Thal, Bart De Strooper
Pages: 1021 - + - Proteomics-based synapse characterization: From proteins to circuits(2023)
Authors: Dan Dascenco, Joris de Wit
- Synaptrode: neural interface at the synapse level(2023)
Authors: Jasper Timmerman, Joris de Wit, Sebastian Haesler
Number of pages: 4 - KIF2A deficiency causes early-onset neurodegeneration(2022)
Authors: Joris de Wit
- MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior(2022)
Authors: Joris de Wit
- Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads(2022)
Authors: Florian De Rop, Jasper Janssens, Koen Theunis, Valerie Christiaens, Jasper Wouters, Gabriele Marcassa, Joris de Wit, Stein Aerts
- Role of regulatory C-terminal motifs in synaptic confinement of LRRTM2(2021)
Authors: Joris de Wit
Pages: 492 - 506
Patents
1 - 3 of 3