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Researcher
Joris de Wit
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Cell signalling, Intracellular compartments and transport, Membrane structure and transport, Cognitive neuroscience, Developmental neuroscience, Neurological and neuromuscular diseases
- See also: De Wit Joris (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Synapse Biology (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2013 → Today - Laboratory of Synapse Biology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - de Wit Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Jan 2013 → 31 Dec 2016
Projects
1 - 10 of 31
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Microglia-synapse molecular interactions in Alzheimer's diseaseFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unravelling the regulatory code orchestrating neural circuit formationFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2021 → TodayFunding: BOF - Methusalem
- Development and Specification of Cortical Layer 1 MicrocircuitsFrom1 Sep 2021 → 22 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of cell-surface receptor signaling mechanisms in dendritic spine maturation and plasticityFrom26 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synapse type-specific multi-omics mapping of sensory experience-induced plasticityFrom1 Nov 2020 → 31 Dec 2022Funding: FWO junior postdoctoral fellowship
- Mapping of input-specific protein repertoires using state-of-the art genome engineering and imaging tools.From1 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping the synaptic proteome through site-specific protein biotinylationFrom1 Oct 2020 → 30 Sep 2023Funding: FWO senior postdoctoral fellowship
- Mapping the cell-surface molecule repertoires patterning hippocampal CA1 border interneuron connectivityFrom15 Sep 2020 → TodayFunding: FWO fellowships
Publications
11 - 20 of 43
- Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer(2020)
Authors: Joris de Wit
- Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model(2020)
Authors: Gabriele Marcassa, Iordana Chrysidou, Joris de Wit, Bart De Strooper
- SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function(2019)
Authors: Ben Verpoort, Joris de Wit
- Compartmentalized distributions of neuronal and glial cell-surface proteins pattern the synaptic network(2019)
Authors: Joris de Wit
Pages: 126 - 133 - Nuclear import of the dscam-cytoplasmic domain drives signaling capable of inhibiting synapse formation(2019)
Authors: Sonja Sachse, Dan Dascenco, Evgenia Salta, Wouter Van Delm, Stéphane Plaisance, Bart De Strooper, Joris de Wit, Dietmar Schmucker
Pages: 1 - 19 - Glypicans as novel regulators of synaptic connectivity(2019)
Authors: Giuseppe Condomitti, Joris de Wit
- Secreted amyloid-beta precursor protein functions as a GABABR1a ligand to modulate synaptic transmission(2019)
Authors: An Schreurs, Julie Nys, Detlef Balschun, Karl Farrow, Bart De Strooper, Joris de Wit
Pages: 143 - 143 - Leucine-rich repeat protein diversity in synapse and circuit function(2018)
Authors: Anna Schroeder, Joris de Wit
- An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses(2018)
Authors: Giuseppe Condomitti, Anna Schroeder, Joris de Wit
Pages: 201 - + - Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors(2018)
Authors: Giuseppe Condomitti, Joris de Wit
Pages: 130 - +
Patents
1 - 3 of 3