Researcher
Gilles De Keulenaer
- Research Expertise:Force-length transducers for cardiovascular and pharmacological research (heartmuscle mechanics).
- Keywords:TRANSDUCER, BIOMECHANICS, CARDIAC MUSCLE, Pharmacy and pharmacology
- Disciplines:Biomechanics, Cardiac and vascular medicine, Physiology
- Research techniques:- Cardiac muscle mechanics - Echocardiography in small animals - Microsurgery in small animals for induction of heart failure - Basic molecular biology - Cell culture - Electrophysiology - Quantitative fluorometry
- Users of research expertise:- Other research groups - Research and product development departments in pharmaceutical companies
Affiliations
- Physiopharmacology (PHYSPHAR) (Research group)
Member
From1 Oct 2011 → Today - Physiology (Research group)
Responsible
From1 Oct 2003 → 30 Sep 2011
Projects
1 - 10 of 26
- Understanding the Effects of Heart Failure Treatments on Cancer Growth.From1 Nov 2023 → TodayFunding: FWO fellowships
- Small-Molecule ERBB4 Agonists to Treat Heart FailureFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Vevo LAZR-X Photoacoustic Imaging System;From1 Jun 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Cardiovascular disease and cancer are linked through the NRG1/ERBB3 signaling system.From26 Feb 2021 → 31 Dec 2021Funding: Other federal public and semi-governmental institutions
- Defining atrial myopathy in aging and disease (DIAMOND consortium).From1 Jan 2021 → TodayFunding: BOF - iBOF
- Studies of the ErbB4 receptor in myocardial non-myocytes to create new opportunities for the treatment of cardiac disease.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Neuregulin-1 as a therapy for atrial fibrillation and the role of the NRG-1/ErbB4 system in atrial remodelling.From1 Jan 2019 → 31 Dec 2022Funding: BOF - projects
- Maternale obesitas en "fetal programming": de gevolgen voor de voortplantingsfysiologie van de nakomelingen.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Identificatie van kleine moleculaire ErbB4 agonisten ter behandeling van cardiovasculaire ziekten.From1 Sep 2018 → 31 Aug 2022Funding: FWO research project (including WEAVE projects)
- Identification of small molecule ErbB4 agonist for treatment of heart failure, diabetic kidney injury and fibrotic disorders.From1 Jan 2018 → 31 Dec 2021Funding: IOF - Industrial Research Fund
Publications
21 - 30 of 79
- Epigenetic regulation of intercellular communication in the heart(2019)
Authors: Vincent Segers, Andreas Gevaert, Jente Boen, Emeline Van Craenenbroeck, Gilles De Keulenaer
Pages: H1417 - H1425 - Treatments targeting inotropy(2019)
Authors: Christoph Maack, Thomas Eschenhagen, Nazha Hamdani, Frank R. Heinzel, Alexander R. Lyon, Dietmar J. Manstein, Joseph Metzger, Zoltan Papp, Carlo G. Tocchetti, M. Birhan Yilmaz, et al.
Pages: 3626 - 3640 - The role of vascular smooth muscle cell contraction and relaxation as active modulators of arterial stiffness(2019)
Authors: Arthur Leloup, Paul Fransen, Gilles De Keulenaer
Number of pages: 233 - Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity(2019)
Authors: Raphaëlle Corremans, Rui Adao, Gilles De Keulenaer, Adelino F. Leite-Moreira, Carmen Bras-Silva
Pages: 204 - 215 - Neuregulin-1 attenuates right ventricular diastolic stiffness in experimental pulmonary hypertension(2019)
Authors: Rui Adao, Pedro Mendes-Ferreira, Carolina Maia-Rocha, Diana Santos-Ribeiro, Patricia Goncalves Rodrigues, Andre Vidal-Meireles, Claudia Monteiro-Pinto, Luis D. Pimentel, Ines Falcao-Pires, Gilles De Keulenaer, et al.
Pages: 255 - 265 - Mechanisms of the multitasking endothelial protein NRG-1 as a compensatory factor during chronic heart failure(2019)
Authors: Gilles De Keulenaer, Eline Feyen, Lindsey Dugaucquier, Hadis Shakeri, Anastasia Shchendrygina, Yury N. Belenkov, Marijke Brink, Zarha Vermeulen, Vincent Segers
- Diabetes-induced cardiomyocyte passive stiffening is caused by impaired insulin-dependent titin modification and can be modulated by neuregulin-1(2018)
Authors: Anna-Eliane Hopf, Christian Andresen, Sebastian Kötter, Malgorzata Isic, Kamila Ulrich, Senem Sahin, Sabine Bongardt, Wilhelm Roell, Felicitas Drove, Nina Scheerer, et al.
Pages: 342 - 355 - Cardiac remodeling(2018)
Authors: Vincent Segers, Dirk L. Brutsaert, Gilles De Keulenaer
- Short-term angiotensin II treatment affects large artery biomechanics and function in the absence of small artery alterations in mice(2018)
Authors: Arthur Leloup, Sofie De Moudt, Cor Van Hove, Lindsey Dugaucquier, Zarha Vermeulen, Vincent Segers, Gilles De Keulenaer, Paul Fransen
- Neuregulin-1 attenuates stress-induced vascular senescence(2018)
Authors: Hadis Shakeri, Andreas Gevaert, Dorien Schrijvers, Guido De Meyer, Gilles De Keulenaer, Pieter-Jan Guns, Katrien Lemmens, Vincent Segers
Pages: 1041 - 1051
Patents
1 - 4 of 4