Researcher
Gilles De Keulenaer
- Research Expertise:Force-length transducers for cardiovascular and pharmacological research (heartmuscle mechanics).
- Keywords:TRANSDUCER, BIOMECHANICS, CARDIAC MUSCLE, Pharmacy and pharmacology
- Disciplines:Biomechanics, Cardiac and vascular medicine, Physiology
- Research techniques:- Cardiac muscle mechanics - Echocardiography in small animals - Microsurgery in small animals for induction of heart failure - Basic molecular biology - Cell culture - Electrophysiology - Quantitative fluorometry
- Users of research expertise:- Other research groups - Research and product development departments in pharmaceutical companies
Affiliations
- Physiopharmacology (PHYSPHAR) (Research group)
Member
From1 Oct 2011 → Today - Physiology (Research group)
Responsible
From1 Oct 2003 → 30 Sep 2011
Projects
1 - 10 of 26
- Understanding the Effects of Heart Failure Treatments on Cancer Growth.From1 Nov 2023 → TodayFunding: FWO fellowships
- Small-Molecule ERBB4 Agonists to Treat Heart FailureFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Vevo LAZR-X Photoacoustic Imaging System;From1 Jun 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Cardiovascular disease and cancer are linked through the NRG1/ERBB3 signaling system.From26 Feb 2021 → 31 Dec 2021Funding: Other federal public and semi-governmental institutions
- Defining atrial myopathy in aging and disease (DIAMOND consortium).From1 Jan 2021 → TodayFunding: BOF - iBOF
- Studies of the ErbB4 receptor in myocardial non-myocytes to create new opportunities for the treatment of cardiac disease.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Neuregulin-1 as a therapy for atrial fibrillation and the role of the NRG-1/ErbB4 system in atrial remodelling.From1 Jan 2019 → 31 Dec 2022Funding: BOF - projects
- Maternale obesitas en "fetal programming": de gevolgen voor de voortplantingsfysiologie van de nakomelingen.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Identificatie van kleine moleculaire ErbB4 agonisten ter behandeling van cardiovasculaire ziekten.From1 Sep 2018 → 31 Aug 2022Funding: FWO research project (including WEAVE projects)
- Identification of small molecule ErbB4 agonist for treatment of heart failure, diabetic kidney injury and fibrotic disorders.From1 Jan 2018 → 31 Dec 2021Funding: IOF - Industrial Research Fund
Publications
31 - 40 of 79
- Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology(2018)
Authors: Christoph Maack, Michael Lehrke, Johannes Backs, Frank R. Heinzel, Jean-Sebastien Hulot, Nikolaus Marx, Walter J. Paulus, Patrick Rossignol, Heinrich Taegtmeyer, Johann Bauersachs, et al.
Pages: 4243 - + - The protective role of NRG-1/ErbB signaling during tissue fibrosis(2017)
Authors: Zarha Vermeulen, Gilles De Keulenaer, Vincent Segers
Number of pages: 204 - The future of pleiotropic therapy in heart failure(2017)
Authors: Gilles De Keulenaer, Vincent Segers, Faiez Zannad, Dirk L. Brutsaert
Pages: 603 - 614 - The autonomic nervous system as a therapeutic target in heart failure(2017)
Authors: Marc van Bilsen, Hitesh C. Patel, Johann Bauersachs, Michael Boehm, Martin Borggrefe, Dirk L. Brutsaert, Andrew J. S. Coats, Rudolf A. de Boer, Gilles De Keulenaer, Gerasimos S. Filippatos, et al.
Pages: 1361 - 1378 - Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in heart, skin and lung(2017)
Authors: Zarha Vermeulen, Anne-Sophie Hervent, Lindsey Dugaucquier, Leni Vandekerckhove, Miche Rombouts, Matthias Beyens, Dorien Schrijvers, Guido De Meyer, Stuart Maudsley, Gilles De Keulenaer, et al.
Pages: H934 - H945 - A novel set-up for the ex vivo analysis of mechanical properties of mouse aortic segments stretched at physiological pressure and frequency(2016)
Authors: Arthur Leloup, Cor E. Van Hove, Ammar Kurdi, Sofie De Moudt, Wim Martinet, Guido De Meyer, Dorien Schrijvers, Gilles De Keulenaer, Paul Fransen
Pages: 6105 - 6115 - Myocardial microvascular inflammatory endothelial activation in heart failure with preserved ejection fraction(2016)
Authors: Constantijn Franssen, Sophia Chen, Andreas Unger, H. Ibrahim Korkmaz, Gilles De Keulenaer, Carsten Tschoepe, Adelino F. Leite-Moreira, Rene Musters, Hans W. M. Niessen, Wolfgang A. Linke, et al.
Pages: 312 - 324 - Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk(2016)
Authors: Leni Vandekerckhove, Zarha Vermeulen, Zhi Zhao Liu, Sonia Boimvaser, Andreas Patzak, Vincent Segers, Gilles De Keulenaer
Pages: E495 - E504 - Effect of angiotensin II-induced arterial hypertension on the voltage-dependent contractions of mouse arteries(2016)
Authors: Paul Fransen, Cor Van Hove, Arthur Leloup, Dorien Schrijvers, Guido De Meyer, Gilles De Keulenaer
Pages: 257 - 267 - Neuregulin-1 improves right ventricular function and attenuates experimental pulmonary arterial hypertension(2016)
Authors: Pedro Mendes-Ferreira, Carolina Maia-Rocha, Rui Adao, Maria Jose Mendes, Diana Santos-Ribeiro, Barbara Silvana Alves, Rui Joao Cerqueira, Paulo Castro-Chaves, Andre Pedro Lourenco, Gilles De Keulenaer, et al.
Pages: 44 - 54
Patents
1 - 4 of 4