Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 72
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 668
- Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts(2020)
Authors: Diether Lambrechts, Chantal Van Ongeval
Pages: 423 - 434 - Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk(2013)
Authors: Diether Lambrechts
- p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity(2016)
Authors: Carmen Adriaens, Jasmine Barra, Annelien Verfaillie, Bram Boeckx, Eleonora Leucci, Joost van den Oord, Anna Sablina, Diether Lambrechts, Stein Aerts, Chris Marine
Pages: 861 - 8 - RNA-sequencing in non-small cell lung cancer shows gene downregulation of therapeutic targets in tumor tissue compared to non-malignant lung tissue(2018)
Authors: Kobe Reynders, Els Wauters, Matthieu Moisse, Paul De Leyn, Maarten Lambrecht, Kristiaan Nackaerts, Christophe Dooms, Wim Janssens, Johan Vansteenkiste, Diether Lambrechts, et al.
- Erratum: Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations(2017)
Authors: David Brown, Dominiek Smeets, Borbála Székely, Denis Larsimont, A Marcell Szász, Pierre-Yves Adnet, Françoise Rothé, Ghizlane Rouas, Zsófia I Nagy, Zsófia Faragó, et al.
Pages: 15759 - Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing(2019)
Authors: Agnieszka Wozniak, Bram Boeckx, Daphne Hompes, Marguerite Stas, Hazem Wafa, Diether Lambrechts, Maria Debiec-Rychter, Raf Sciot, Patrick Schöffski
Pages: 1168 - 1178 - Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease(2010)
Authors: Wim Janssens, Lieven Dupont, Johan Van Eldere, Séverine Vermeire, Diether Lambrechts, Kristiaan Nackaerts, Marc Decramer, Jean-Jacques Cassiman, Harry Cuppens
Pages: 163 - 169 - Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk(2015)
Authors: Diether Lambrechts, Stefanie Schrauwen, Frédéric Amant, Jeroen Depreeuw, Matthieu Moisse
Pages: 231 - 45 - Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study(2016)
Authors: Diether Lambrechts, Ignace Vergote, Els Van Nieuwenhuysen
Pages: 884 - 95 - Single-cell phenotyping to unravel the immunopathology of immune checkpoint inhibitor-related pneumonitis. Lessons learnt from the COVID-19 pandemic(2023)
Authors: Pierre Van Mol, Els Wauters, Johan Vansteenkiste, Diether Lambrechts