Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Projects
41 - 50 of 71
- Postpartum breast cancer diagnosed during the post-weaning period: a distinct entity with unique clinicopathological, molecular and immunological features?From22 Sep 2015 → 9 Jan 2023Funding: Private funding of national origin - undefined
- Combining metabolomics and genomics technologies to study platinum-based therapeutic failure in high grade ovarian cancers: from predictive signature(s) to novel therapeutic strategies.From1 Sep 2015 → 31 Aug 2019Funding: Private funding of national origin - undefined
- Assessment of differences in the anti-tumor immune response between lung cancer patients with and without COPD.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Hypoxia-mediated DNA demethylation events underlying adaptive resistance to anti-angiogenic therapies.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Platform for integrating psychological, pneumological, genetic, rehabilitative, immunological and neural aspects of dyspneaFrom10 Sep 2014 → 9 Mar 2019Funding: Hercules - Small and Medium size research infrastructure
- Metabolism enhances tumorigenesis by alterations that mitigate 5mC oxidation and result in the formation of epimutationsFrom1 Jan 2014 → 31 Dec 2014Funding: FWO research grant KAN
- The effect of changes in the innate and adaptive immune compartment within the renal allograft on graft outcomeFrom1 Oct 2013 → 30 Sep 2018Funding: FWO fellowships
- Mutation profiles and targeted treatment options for mismatch repair deficient tumors.From1 Jan 2013 → 31 Dec 2014Funding: Private funding of national origin - undefined
- Preclinical evaluation of targeted therapies in endometrial cancer: use of primary in vitro and in vivo models.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Mutation profiles and targeted treatment options for mismatch repair deficient tumorsFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 664
- LINC00461 promotes cell migration and invasion in breast cancer through miR-30a-5p/integrin β3 axis(2019)
Authors: Junbin Qian
Pages: 4851 - 4862 - Small cell lung cancer: circulating tumor cell lines and expression of mediators of angiogenesis and coagulation.(2023)
Authors: Bram Boeckx
Pages: 355 - 365 - Insm1 regulates mTEC development and immune tolerance(2023)
Authors: Jieyi Xiong
Pages: 1472 - 1486 - The AI-2 dependent regulator LsrR has a limited regulon in Salmonella Typhimurium(2010)
Authors: Inge Thijs, Hui Zhao, Kristof Engelen, Jos Vanderleyden, Kathleen Marchal, Sigrid De Keersmaecker
Pages: 966 - 969 - Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium(2016)
Authors: Laurien Van Dyck, Ann Smeets
Pages: 137 - 154 - Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.(2018)
Authors: Suzanne C Dixon-Suen, Christina M Nagle, Aaron P Thrift, Paul DP Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Australian Ovarian Cancer Study Group, Georgia Chenevix-Trench, Peter A Fasching, et al.
Pages: 1123 - 1129 - A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (vol 12, 1078, 2021)(2021)
Authors: Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, et al.
- Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF delta/delta mouse model of amyotrophic lateral sclerosis(2010)
Authors: Filip Claes, Diether Lambrechts, Peter Carmeliet
Pages: 203 - Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII plus innate immune cells in rejection(2023)
Authors: Yannick Van Herck, Frederik De Smet, Katrien De Vusser, Dirk Kuypers, Diether Lambrechts, Elisabet Van Loon, Thibaut Vaulet, Francesca Bosisio, Maarten Naesens
- The old antibiotic acriflavine inhibits epithelial-to-mesenchymal transition and the unfolded protein response thereby resensitizing resistant hepatoma cells to sorafenib(2016)
Authors: Jeroen Dekervel, Ashenafi Shiferaw Bulle, Petra Windmolders, Diether Lambrechts, Eric Van Cutsem, Chris Verslype
Pages: 245